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Gomisin G

Name: Gomisin G
Brand: TargetMol
SKU: TQ0217
Price: 459 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TQ0217Cas No. 62956-48-3

Gomisin G is a natural compound and exhibits potent anti-HIV activity (EC50: 0.006 μg/mL; therapeutic index: 300). It is a good substrate of CYP2C9.

Gomisin G

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Purity: 99.98%

Catalog No. TQ0217Cas No. 62956-48-3

Gomisin G is a natural compound and exhibits potent anti-HIV activity (EC50: 0.006 μg/mL; therapeutic index: 300). It is a good substrate of CYP2C9.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$64	In Stock	In Stock
5 mg	$172	In Stock	In Stock
10 mg	$271	In Stock	In Stock
25 mg	$459	In Stock	In Stock
50 mg	Preferential	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$197	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.98%

Appearance:Solid

Color:White

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COA LCMS

Product Introduction

Gomisin G AI Summary

Gomisin G exhibits significant antiviral activity against HIV, with an EC50 of 0.006 μg/mL and an IC50 value of 11.0 nM. It is also effective in inhibiting TPA-induced EBV-early antigen activation in human Raji cells, particularly at a 10 mol ratio relative to TPA, though it shows cytotoxic effects at higher ratios (1000 mol) as determined by trypan blue staining. Additionally, Gomisin G demonstrates antioxidant properties in human HL60 cells by inhibiting TPA-stimulated hydrogen peroxide-induced DCFH-DA oxidation with an IC50 value of 38200.0 nM and shows cytotoxicity with an IC50 value of 48300.0 nM in the XTT assay. It significantly inhibits human PBMC proliferation at a concentration of 100 μM, with inhibitory effects ranging from 46.2% to 88.6% in various assays involving PHA stimulation. The compound has a therapeutic index of 600.0, suggesting a wide margin of safety. Furthermore, it displays robust activity in inhibiting P-gp-mediated doxorubicin efflux in human HL60/MDR cells, with an activity of 199.0% at a concentration of 25 μM after 15 minutes of preincubation, as measured by flow cytometry. These diverse bioactivities emphasize its potential therapeutic applications across multiple cell lines and conditions..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Gomisin G is a natural compound and exhibits potent anti-HIV activity (EC50: 0.006 μg/mL; therapeutic index: 300). It is a good substrate of CYP2C9.
Targets&IC50	HIV protease:0.006 μg/mL(EC50)

Chemical Properties

Molecular Weight	536.57
Formula	C₃₀H₃₂O₉
Cas No.	62956-48-3
Smiles	COc1cc2C[C@H](C)[C@](C)(O)[C@@H](OC(=O)c3ccccc3)c3cc4OCOc4c(OC)c3-c2c(OC)c1OC
Relative Density.	1.33 g/cm3 at 20℃

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (83.87 mM), Sonication is recommended.

H2O: Insoluble

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (3.73 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8637 mL	9.3184 mL	18.6369 mL	93.1845 mL
5 mM	0.3727 mL	1.8637 mL	3.7274 mL	18.6369 mL
10 mM	0.1864 mL	0.9318 mL	1.8637 mL	9.3184 mL
20 mM	0.0932 mL	0.4659 mL	0.9318 mL	4.6592 mL
50 mM	0.0373 mL	0.1864 mL	0.3727 mL	1.8637 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc