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Ceftolozane sulfate

Name: Ceftolozane sulfate
Brand: TargetMol
SKU: T30790
Price: 456 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: FR-264205, FR264205, FR 264205, CXA-101 sulfate, CXA101 sulfate) Copy Product Info

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Synonyms: FR-264205, FR264205, FR 264205, CXA-101 sulfate, CXA101 sulfate

Catalog No. T30790 Copy Product Info

Purity: 97.49%

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Ceftolozane sulfate (FR-264205/CXA-101) is a cephalosporin antibiotic, a penicillin-binding protein (PBP) inhibitor with antipseudomonal activity, used for infection research including pneumonia.

Cas No. 936111-69-2

Pack Size	Price	USA Stock	Global Stock
1 mg	$456	In Stock	In Stock
5 mg	$1,130	-	In Stock
10 mg	$1,520	-	In Stock
1 mL x 10 mM (in DMSO)	$1,460	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:97.49%

Appearance:Solid

Color:White

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COA HNMR

Product Introduction

Bioactivity

Description	Ceftolozane sulfate (FR-264205/CXA-101) is a cephalosporin antibiotic, a penicillin-binding protein (PBP) inhibitor with antipseudomonal activity, used for infection research including pneumonia.
Targets & IC50	Carbapenem-resistant Pseudomonas aeruginosa:> 8 μg/mL (MIC), Pseudomonas aeruginosa:4 mg/L (MIC), P. aeruginosa PAO1:0.5 μg/mL (MIC)
In vitro	Methods: Carbapenem-resistant and multidrug-resistant (MDR) Pseudomonas aeruginosa isolates were treated with various concentrations of Ceftolozane sulfate (≤0.12->64 μg/mL), and MIC values were determined. Results: Ceftolozane sulfate exhibited anti-pseudomonal activity against these resistant isolates; among 11 carbapenem-resistant isolates, 4.7% (i.e., 1 isolate) had MIC >8 μg/mL. [1] Methods: The in vitro activity of ceftolozane/tazobactam was determined in Pseudomonas aeruginosa and Enterobacterales by broth microdilution method. Results: The susceptibility rates of ceftolozane/tazobactam were 95.8%–97.5% for Pseudomonas aeruginosa and 93.3%–95.6% for Enterobacterales. [2]
In vivo	Methods: A neutropenic CD-1 mouse thigh infection model was used. Ceftolozane sulfate was administered by intraperitoneal injection at doses of 2–128 mg/kg every 2 hours for 24 hours, with sterile normal saline as the vehicle. Results: Ceftolozane sulfate monotherapy was effective against some Enterobacteriaceae strains but had limited activity against ESBL-producing strains; combination with tazobactam significantly enhanced efficacy.[3] Methods: A high inoculum mouse peritonitis model was used. Ceftolozane sulfate (100/50 mg/kg) was administered by intraperitoneal injection every 2 hours for 24 hours, with sterile normal saline as the vehicle. Results: The in vivo activity of Ceftolozane sulfate against CTX-M-15-producing Escherichia coli was lower than that of imipenem, with higher bacterial counts.[4]
Synonyms	FR-264205, FR264205, FR 264205, CXA-101 sulfate, CXA101 sulfate

Chemical Properties

Molecular Weight	764.77
Formula	C₂₃H₃₂N₁₂O₁₂S₃
Cas No.	936111-69-2
Smiles	S(=O)(=O)([O-])O.C(O)(=O)C=1N2[C@@]([C@H](NC(/C(=N\OC(C(O)=O)(C)C)/C3=NSC(N)=N3)=O)C2=O)(SCC1C[N+]4=CC(NC(NCCN)=O)=C(N)N4C)[H]
Relative Density.	no data available

Storage & Solubility Information

Storage

Store at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 5 mg/mL (6.54 mM), Sonication is recommended.

DMSO: 40 mg/mL (52.3 mM), Sonication is recommended.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	1.3076 mL	6.5379 mL	13.0758 mL	65.3791 mL
5 mM	0.2615 mL	1.3076 mL	2.6152 mL	13.0758 mL

DMSO

	1mg	5mg	10mg	50mg
10 mM	0.1308 mL	0.6538 mL	1.3076 mL	6.5379 mL
20 mM	0.0654 mL	0.3269 mL	0.6538 mL	3.2690 mL
50 mM	0.0262 mL	0.1308 mL	0.2615 mL	1.3076 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Bacterial

Related Tags: Ceftolozane sulfate chemical structure | Ceftolozane sulfate in vivo | Ceftolozane sulfate in vitro | Ceftolozane sulfate formula | Ceftolozane sulfate molecular weight