Shopping Cart

Remove All

Your shopping cart is currently empty

Proceed to checkout Continue shopping

KY-556

Name: KY-556
Brand: TargetMol
SKU: T15676
Rating: 4.5 (1 reviews)

😃Good

Catalog No. T15676Cas No. 110816-78-9

Alias N556

KY-556 is a promising, orally-active pro-drug of disodium cromoglycate (DSCG) effective against allergic diseases.

KY-556

😃Good

Catalog No. T15676Alias N556Cas No. 110816-78-9

KY-556 is a promising, orally-active pro-drug of disodium cromoglycate (DSCG) effective against allergic diseases.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
50 mg	$789	6-8 weeks	6-8 weeks
100 mg	$1,240	6-8 weeks	6-8 weeks

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Resource Download

Product Introduction

Bioactivity

Description	KY-556 is a promising, orally-active pro-drug of disodium cromoglycate (DSCG) effective against allergic diseases.
In vivo	N-556, administered orally at a dosage of 100 mg/kg, has been shown to extend survival times in rats experiencing systemic anaphylaxis and to significantly reduce airway resistance in rat models of experimental asthma. Furthermore, N-556 demonstrated a dose-dependent inhibition of 48-hour homologous passive cutaneous anaphylaxis (PCA) in rats, with effects persisting longer than those observed with Disodium cromoglycate (DSCG) administered intravenously. The compound's oral anti-allergic properties were further confirmed through a regimen of 20 and 100 mg/kg daily for 20 days, which notably suppressed histamine release from lung fragments of actively sensitized rats.
Synonyms	N556

Chemical Properties

Molecular Weight	689.11
Formula	C₃₃H₃₇ClN₂O₁₂
Cas No.	110816-78-9
Smiles	Cl.Cl.CCOC(=O)c1cc(=O)c2c(OCC(COc3cccc4oc(cc(=O)c34)C(=O)OCC)OC(=O)[C@@H](N)CCCCN)cccc2o1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

N-556N 556KY-556KY556KY 556