Powder: -20°C for 3 years | In solvent: -80°C for 1 year
MCI, a chemical compound demonstrating significant anti-inflammatory effects, particularly in collagen-induced arthritis (CIA) models, modulates inflammation through macrophage reprogramming by enhancing ROS scavenging and promoting COX-2 downregulation. It effectively inhibits COX-2, exhibiting an IC50 of 1.23 μM. Additionally, MCI holds potential for research applications in rheumatoid arthritis (RA) [1].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | Inquiry | Inquiry | |
50 mg | Inquiry | Inquiry |
Description | MCI, a chemical compound demonstrating significant anti-inflammatory effects, particularly in collagen-induced arthritis (CIA) models, modulates inflammation through macrophage reprogramming by enhancing ROS scavenging and promoting COX-2 downregulation. It effectively inhibits COX-2, exhibiting an IC50 of 1.23 μM. Additionally, MCI holds potential for research applications in rheumatoid arthritis (RA) [1]. |
Targets&IC50 | COX-2:1.23 μM |
In vitro | MCI (8 μM, 2 h) suppresses the production of ROS and the expression of COX-2 in LPS-stimulated RAW 264.7 cells, consequently inducing a phenotypic shift in macrophages from the M1 to the M2 type [1]. |
In vivo | MCI (1.05 mg/kg, intra-articular injection, once every three days for 18 days) can prevent the progression of RA and has a significant anti-inflammatory effect [1]. |
Molecular Weight | 934.39 |
Formula | C45H52ClN7O13 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
MCI Immunology/Inflammation Metabolism NF-Κb Reactive Oxygen Species inhibitor inhibit