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JGB-1-155 is a positive allosteric modulator of nicotinamide phosphoribosyltransferase that enhances NAMPT enzymatic activity, elevates intracellular NAD⁺ levels in human monocytes, counteracts oxidative stress, and attenuates TNFα-induced reactive oxygen species production, supporting its application in studies of redox balance and inflammatory signaling.

| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 mg | $1,520 | 8-10 weeks | 8-10 weeks | |
| 50 mg | $1,980 | 8-10 weeks | 8-10 weeks | |
| 100 mg | $2,500 | 8-10 weeks | 8-10 weeks |
| Description | JGB-1-155 is a positive allosteric modulator of nicotinamide phosphoribosyltransferase that enhances NAMPT enzymatic activity, elevates intracellular NAD⁺ levels in human monocytes, counteracts oxidative stress, and attenuates TNFα-induced reactive oxygen species production, supporting its application in studies of redox balance and inflammatory signaling. |
| In vitro | In biochemical assays, JGB-1-155 significantly activated the NAMPT enzyme with an EC50 of 0.026 μM and protected the cells from oxidative stress-induced death [1]. |
| Synonyms | JGB1-155 |
| Molecular Weight | 426.59 |
| Formula | C26H38N2O3 |
| Cas No. | 3011930-28-9 |
| Smiles | O=C(C=1OC=CC1)N(CC2=CC=C(C=C2)N(C)C)CCC3(CCOC(C)(C)C3)C(C)C |
| Storage | In solvent: -80°C for 1 year | Shipping with blue ice. |
Dissolve 2 mg of the compound in 100 μL DMSO
to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
1) Add 100 μL of the DMSO
stock solution to 400 μL PEG300
and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O
and mix thoroughly until a homogeneous solution is obtained.
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