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Posenacaftor sodium

Name: Posenacaftor sodium
Brand: TargetMol
SKU: T36519
Rating: 4.5 (1 reviews)

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Catalog No. T36519Cas No. 2095064-06-3

Posenacaftor (PTI-801) sodium, a cystic fibrosis transmembrane regulator (CFTR) modulator, corrects CFTR protein folding and trafficking. It is utilized in researching cystic fibrosis (CF)[1].

Posenacaftor sodium

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Catalog No. T36519Cas No. 2095064-06-3

Posenacaftor (PTI-801) sodium, a cystic fibrosis transmembrane regulator (CFTR) modulator, corrects CFTR protein folding and trafficking. It is utilized in researching cystic fibrosis (CF)[1].

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$1,520	6-8 weeks	6-8 weeks
50 mg	$1,980	6-8 weeks	6-8 weeks
100 mg	$2,500	6-8 weeks	6-8 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description

Posenacaftor (PTI-801) sodium, a cystic fibrosis transmembrane regulator (CFTR) modulator, corrects CFTR protein folding and trafficking. It is utilized in researching cystic fibrosis (CF)[1].

In vitro

Cystic fibrosis (CF) is an autosomal recessive disorder caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene[1]. These mutations result in the production of a defective CFTR protein, impairing ion flow across cell membranes, particularly at the apical membrane of epithelial cells[1]. Posenacaftor serves as a CFTR corrector, a compound designed to repair and restore functional activity to the malfunctioning CFTR protein. Once corrected, CFTR can relocate to the cell surface, acting as a chloride channel to regulate fluid balance in the airways[2].

Chemical Properties

Molecular Weight	468.505
Formula	C₂₇H₂₇NNaO₅
Cas No.	2095064-06-3
Smiles	[Na].C[C@@H](Oc1ccc(C)c2nc(cc(C(O)=O)c12)-c1oc2ccccc2c1C)C1CCOCC1jcExt:v:0:0

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 200 mg/mL (426.89 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1344 mL	10.6722 mL	21.3445 mL	106.7224 mL
5 mM	0.4269 mL	2.1344 mL	4.2689 mL	21.3445 mL
10 mM	0.2134 mL	1.0672 mL	2.1344 mL	10.6722 mL
20 mM	0.1067 mL	0.5336 mL	1.0672 mL	5.3361 mL
50 mM	0.0427 mL	0.2134 mL	0.4269 mL	2.1344 mL
100 mM	0.0213 mL	0.1067 mL	0.2134 mL	1.0672 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc