Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Posenacaftor (PTI-801) sodium, a cystic fibrosis transmembrane regulator (CFTR) modulator, corrects CFTR protein folding and trafficking. It is utilized in researching cystic fibrosis (CF)[1].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 6-8 weeks | $ 1,520.00 | |
50 mg | 6-8 weeks | $ 1,980.00 | |
100 mg | 6-8 weeks | $ 2,500.00 |
Description | Posenacaftor (PTI-801) sodium, a cystic fibrosis transmembrane regulator (CFTR) modulator, corrects CFTR protein folding and trafficking. It is utilized in researching cystic fibrosis (CF)[1]. |
In vitro | Cystic fibrosis (CF) is an autosomal recessive disorder caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene[1]. These mutations result in the production of a defective CFTR protein, impairing ion flow across cell membranes, particularly at the apical membrane of epithelial cells[1]. Posenacaftor serves as a CFTR corrector, a compound designed to repair and restore functional activity to the malfunctioning CFTR protein. Once corrected, CFTR can relocate to the cell surface, acting as a chloride channel to regulate fluid balance in the airways[2]. |
Molecular Weight | 468.505 |
Formula | C27H27NNaO5 |
CAS No. | 2095064-06-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 200 mg/mL (427.82 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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Posenacaftor sodium 2095064-06-3 inhibitor inhibit