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T-10418
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Catalog No. T88533Cas No. 1608784-68-4
T-10418 is a highly potent and selective G2A/GPR132 agonist (EC50 = 0.82 μM) that enhances TRPV1 responses in mouse primary sensory neurons, making it suitable for studying neuropathic pain and inflammation.
T-10418
🥰Excellent
Purity: 98.95%
Catalog No. T88533Cas No. 1608784-68-4
T-10418 is a highly potent and selective G2A/GPR132 agonist (EC50 = 0.82 μM) that enhances TRPV1 responses in mouse primary sensory neurons, making it suitable for studying neuropathic pain and inflammation.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $142 | In Stock | |
| 5 mg | $355 | In Stock | |
| 10 mg | $569 | In Stock | |
| 25 mg | $1,180 | In Stock | |
| 50 mg | $1,620 | In Stock | |
| 100 mg | $2,180 | In Stock | |
| 200 mg | $2,930 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $389 | In Stock |
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Purity:98.95%
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Product Introduction
Bioactivity
Chemical Properties
| Description | T-10418 is a highly potent and selective G2A/GPR132 agonist (EC50 = 0.82 μM) that enhances TRPV1 responses in mouse primary sensory neurons, making it suitable for studying neuropathic pain and inflammation. |
| In vitro | Methods: T-10418 was applied at 100 nM to primary mouse sensory neurons for 4 minutes to assess its effect on TRPV1 responses induced by capsaicin. In parallel, Molm13 and ML-2 leukemia cells were treated with 30 μM T-10418 for 72 hours to evaluate its impact on cell proliferation and viability. Results: T-10418 (100 nM, 4 minutes) significantly enhanced TRPV1 responses. At 30 μM for 72 hours, T-10418 had no significant effect on the proliferation or viability of Molm13 and ML-2 cells.[1] |
| Molecular Weight | 376.41 |
| Formula | C22H20N2O4 |
| Cas No. | 1608784-68-4 |
| Smiles | C(N[C@H](CC1=CC=CC=C1)C(O)=O)(=O)C2=CC(OCC=3C=CC=NC3)=CC=C2 |
| Color | Yellow |
| Appearance | Solid |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 80 mg/mL (212.53 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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