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T-10418
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Catalog No. T88533Cas No. 1608784-68-4
T-10418 is a highly potent and selective G2A/GPR132 agonist (EC50 = 0.82 μM) that enhances TRPV1 responses in mouse primary sensory neurons, making it suitable for studying neuropathic pain and inflammation.
T-10418
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Purity: 98.95%
Catalog No. T88533Cas No. 1608784-68-4
T-10418 is a highly potent and selective G2A/GPR132 agonist (EC50 = 0.82 μM) that enhances TRPV1 responses in mouse primary sensory neurons, making it suitable for studying neuropathic pain and inflammation.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $142 | In Stock | In Stock | |
| 5 mg | $355 | In Stock | In Stock | |
| 10 mg | $569 | In Stock | In Stock | |
| 25 mg | $1,180 | In Stock | In Stock | |
| 50 mg | $1,620 | In Stock | In Stock | |
| 100 mg | $2,180 | - | In Stock | |
| 200 mg | $2,930 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $389 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:98.95%
Appearance:Solid
Color:Yellow
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Product Introduction
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Chemical Properties
Storage & Solubility Information
| Description | T-10418 is a highly potent and selective G2A/GPR132 agonist (EC50 = 0.82 μM) that enhances TRPV1 responses in mouse primary sensory neurons, making it suitable for studying neuropathic pain and inflammation. |
| In vitro | Methods: T-10418 was applied at 100 nM to primary mouse sensory neurons for 4 minutes to assess its effect on TRPV1 responses induced by capsaicin. In parallel, Molm13 and ML-2 leukemia cells were treated with 30 μM T-10418 for 72 hours to evaluate its impact on cell proliferation and viability. Results: T-10418 (100 nM, 4 minutes) significantly enhanced TRPV1 responses. At 30 μM for 72 hours, T-10418 had no significant effect on the proliferation or viability of Molm13 and ML-2 cells.[1] |
| Molecular Weight | 376.41 |
| Formula | C22H20N2O4 |
| Cas No. | 1608784-68-4 |
| Smiles | C(N[C@H](CC1=CC=CC=C1)C(O)=O)(=O)C2=CC(OCC=3C=CC=NC3)=CC=C2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 80 mg/mL (212.53 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+90% Corn Oil: 5 mg/mL (13.28 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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