Shopping Cart

Your shopping cart is currently empty

Terutroban

Name: Terutroban
Brand: TargetMol
SKU: T5505
Price: 46 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

🥰Excellent

Catalog No. T5505Cas No. 165538-40-9

Terutroban, a thromboxane prostaglandin receptor antagonist, affects the progression of atherosclerosis.

Terutroban

Copy Product Info

🥰Excellent

Purity: 99.53%

Catalog No. T5505Cas No. 165538-40-9

Terutroban, a thromboxane prostaglandin receptor antagonist, affects the progression of atherosclerosis.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$46	In Stock	In Stock
10 mg	$71	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$56	In Stock	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.53%

Appearance:Solid

Color:White

Resource Download

COA LCMS

Product Introduction

Terutroban AI Summary

Terutroban exhibits antagonist activity against the human thromboxane A2 receptor alpha with an IC50 value of 16.4 nM, as assessed through the reduction of I-BOP-induced inositol monophosphate production in QBI-HEK293A cells. This compound also shows antiviral effects, inhibiting SARS-CoV-2 induced cytotoxicity in both Caco-2 and VERO-6 cells at 10 µM concentration, though with relatively low inhibition percentages of 5.7% and -0.15%, respectively. Additionally, it inhibits SARS-CoV-2 3CL-Pro protease activity by 2.655% at 20 µM concentration. Moreover, Terutroban demonstrates inhibitory activity on the human HDAC6 enzyme, with an inhibition of 3.38% using a commercial peptide substrate and just 0.11% with a custom peptide substrate. It also affects cell viability differently across cell lines, enhancing growth in HEK293T cells but inhibiting it in U2OS and human fibroblast cells, indicating a variable bioactivity profile. In terms of protein thermal stability, Terutroban has mixed effects, increasing the melting temperature in some protein regions by 0.1 to 0.54 degrees Celsius while decreasing it in others by -0.38 to -2.74 degrees Celsius, which suggests complex, domain-specific protein interactions. Furthermore, the compound impacts GPCR beta-arrestin recruitment, exhibiting both agonistic and inhibitory effects on targets such as GLP1R, GPR35, AGTR1, C5AR1, FPR2, S1PR1, ADRB2, GPR119, CX3CR1, APLNR, FFAR4, and ADRA2A. This indicates Terutroban's potential modulatory role in various GPCR signaling pathways relevant to diverse physiological processes..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

Terutroban, a thromboxane prostaglandin receptor antagonist, affects the progression of atherosclerosis.

Chemical Properties

Molecular Weight	407.91
Formula	C₂₀H₂₂ClNO₄S
Cas No.	165538-40-9
Smiles	Cc1ccc2C[C@@H](CCc2c1CCC(O)=O)NS(=O)(=O)c1ccc(Cl)cc1
Relative Density.	1.389g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: ≥ 22 mg/mL (53.93 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.9 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4515 mL	12.2576 mL	24.5152 mL	122.5761 mL
5 mM	0.4903 mL	2.4515 mL	4.9030 mL	24.5152 mL
10 mM	0.2452 mL	1.2258 mL	2.4515 mL	12.2576 mL
20 mM	0.1226 mL	0.6129 mL	1.2258 mL	6.1288 mL
50 mM	0.0490 mL	0.2452 mL	0.4903 mL	2.4515 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc