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Flunixin meglumine

Name: Flunixin meglumine
Brand: TargetMol
SKU: T1209
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1209Cas No. 42461-84-7

Alias Flunixin meglumin, Finadyne, Banamine

Flunixin meglumine (Banamine) is an effective inhibitor of the enzyme cyclooxygenase with anti-inflammatory and antipyretic activity.

Flunixin meglumine

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Purity: 99.57%

Catalog No. T1209Alias Flunixin meglumin, Finadyne, BanamineCas No. 42461-84-7

Flunixin meglumine (Banamine) is an effective inhibitor of the enzyme cyclooxygenase with anti-inflammatory and antipyretic activity.

Pack Size	Price	USA Warehouse	Global Warehouse
1 g	$40	-	In Stock
5 g	$92	-	In Stock
10 g	$135	-	In Stock
1 mL x 10 mM (in DMSO)	$30	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.57%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Flunixin meglumine AI Summary

Flunixin meglumine exhibits significant antiviral activity against JC polyomavirus M1/SVEdelta in human SVG-A cells by inhibiting viral replication with an EC50 of 14500.0 nM and displays a therapeutic index ratio greater than 2.0. Additionally, the compound shows cytotoxicity in SVG-A cells with a TC50 greater than 40.0 µM, and a cytotoxicity ratio exceeding 3.0. It also has bioactivities in various assays, including inducing genotoxicity in human embryonic kidney cells expressing luciferase-tagged ELG1, delayed death inhibition in malarial parasites, acting as a firefly luciferase inhibitor/activator, inducing DNA re-replication in SW480 colon adenocarcinoma cells, and showing potency as a TDP-43 inhibitor. For SARS-CoV-2, Flunixin meglumine inhibits virus-induced cytotoxicity in Caco-2 and VERO-6 cells, with 25.38% inhibition at 10 µM after 48 hours in Caco-2 cells. However, it did not show significant antiviral activity in HRCE cells against the USA-WA1/2020 strain and exhibited a modest inhibition of 13.07% of the SARS-CoV-2 3CL-Pro protease at 20 µM..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Flunixin meglumine (Banamine) is an effective inhibitor of the enzyme cyclooxygenase with anti-inflammatory and antipyretic activity.
Targets&IC50	COX-1:17 nM (IC50), COX-2:0.4 nM (IC50)
Synonyms	Flunixin meglumin, Finadyne, Banamine

Chemical Properties

Molecular Weight	491.46
Formula	C₂₁H₂₈F₃N₃O₇
Cas No.	42461-84-7
Smiles	CC1=C(C=CC=C1NC2=C(C=CC=N2)C(=O)O)C(F)(F)F.CNC[C@@H]([C@H]([C@@H]([C@@H](CO)O)O)O)O
Relative Density.	1.403 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (101.74 mM), Sonication is recommended.

H2O: 90 mg/mL (183.13 mM), Sonication is recommended.

Ethanol: 8 mg/mL (16.28 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.07 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	2.0348 mL	10.1738 mL	20.3475 mL	101.7377 mL
5 mM	0.4070 mL	2.0348 mL	4.0695 mL	20.3475 mL
10 mM	0.2035 mL	1.0174 mL	2.0348 mL	10.1738 mL

DMSO/H2O

	1mg	5mg	10mg	50mg
20 mM	0.1017 mL	0.5087 mL	1.0174 mL	5.0869 mL
50 mM	0.0407 mL	0.2035 mL	0.4070 mL	2.0348 mL
100 mM	0.0203 mL	0.1017 mL	0.2035 mL	1.0174 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc