Omzotirome

Name: Omzotirome
Brand: TargetMol
SKU: T38483
Rating: 4.5 (1 reviews)

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Catalog No. T38483Cas No. 1092551-88-6

Alias TRC-150094

Omzotirome (TRC150094) is a functional analog of iodothyronines and holds potential for research on hyperlipidemia (WO2008149379).

Omzotirome

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Catalog No. T38483Alias TRC-150094Cas No. 1092551-88-6

Omzotirome (TRC150094) is a functional analog of iodothyronines and holds potential for research on hyperlipidemia (WO2008149379).

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Product Introduction

Bioactivity

Description	Omzotirome (TRC150094) is a functional analog of iodothyronines and holds potential for research on hyperlipidemia (WO2008149379).
In vivo	Omzotirome (0.750 mg/100 g; i.p.) administration in male Wistar rats (8 weeks old) on a high-fat diet (HFD) markedly reduces visceral adipose tissue compared to HFD counterparts, simultaneously altering metabolism in two metabolically active major tissues. This results in enhanced energy expenditure and fatty acid oxidation, culminating in body weight gain similar to rats fed a standard chow. Omzotirome acts as a functional analog of iodothyronines, effectively decreasing adiposity by boosting metabolic rates in response to a high-fat dietary intake[1].
Synonyms	TRC-150094

Chemical Properties

Molecular Weight	328.412
Formula	C₁₉H₂₄N₂O₃
Cas No.	1092551-88-6
Smiles	Cc1nn(CCC(O)=O)c(C)c1Cc1cc(C)c(O)c2CCCc12

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

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