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Lifitegrast sodium

Name: Lifitegrast sodium
Brand: TargetMol
SKU: T3977L
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T3977LCas No. 1119276-80-0

Alias Xiidra sodium, SHP-606 sodium, SAR1118-023 sodium, SAR-1118-023 sodium, SAR 1118-023 sodium

Lifitegrast sodium (SAR-1118-023 sodium) is a small molecule integrin antagonist that inhibits T cell-mediated inflammation by blocking the binding of two important cell surface proteins (lymphocyte function-associated antigen 1 and intercellular adhesion molecule 1), which reduces inflammation of the ocular surface, and may be used in the study of dry eye.

Lifitegrast sodium

🥰Excellent

Purity: 99.33%

Catalog No. T3977LAlias Xiidra sodium, SHP-606 sodium, SAR1118-023 sodium, SAR-1118-023 sodium, SAR 1118-023 sodiumCas No. 1119276-80-0

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mg	$29	-	In Stock
5 mg	Preferential	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.33%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Lifitegrast sodium (SAR-1118-023 sodium) is a small molecule integrin antagonist that inhibits T cell-mediated inflammation by blocking the binding of two important cell surface proteins (lymphocyte function-associated antigen 1 and intercellular adhesion molecule 1), which reduces inflammation of the ocular surface, and may be used in the study of dry eye.
Synonyms	Xiidra sodium, SHP-606 sodium, SAR1118-023 sodium, SAR-1118-023 sodium, SAR 1118-023 sodium

Chemical Properties

Molecular Weight	637.46
Formula	C₂₉H₂₃Cl₂N₂NaO₇S
Cas No.	1119276-80-0
Smiles	ClC1=C2C(CN(CC2)C(C3=CC=C(C=CO4)C4=C3)=O)=CC(Cl)=C1C(N[C@H](C([O-])=O)CC5=CC(S(C)(=O)=O)=CC=C5)=O.[Na+]
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 80 mg/mL (125.50 mM), Sonication is recommended.

DMSO: 80 mg/mL (125.50 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (5.18 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	1.5687 mL	7.8436 mL	15.6873 mL	78.4363 mL
5 mM	0.3137 mL	1.5687 mL	3.1375 mL	15.6873 mL
10 mM	0.1569 mL	0.7844 mL	1.5687 mL	7.8436 mL
20 mM	0.0784 mL	0.3922 mL	0.7844 mL	3.9218 mL
50 mM	0.0314 mL	0.1569 mL	0.3137 mL	1.5687 mL
100 mM	0.0157 mL	0.0784 mL	0.1569 mL	0.7844 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc