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AGI-24512

🥰Excellent
Catalog No. T14141Cas No. 2201066-53-5

AGI-24512 is a potent inhibitor of methionine adenylyltransferase 2α (MAT2A) (IC50: 8 nM).AGI-24512 shows antiproliferative activity in MTAP-deficient cancer cells.AGI-24512 inhibits MAT2A, which causes DNA damage in MTAP, and is often used in conjunction with anticancer compounds in cancer research.

AGI-24512

AGI-24512

🥰Excellent
Purity: 98.55%
Catalog No. T14141Cas No. 2201066-53-5
AGI-24512 is a potent inhibitor of methionine adenylyltransferase 2α (MAT2A) (IC50: 8 nM).AGI-24512 shows antiproliferative activity in MTAP-deficient cancer cells.AGI-24512 inhibits MAT2A, which causes DNA damage in MTAP, and is often used in conjunction with anticancer compounds in cancer research.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$64In StockIn Stock
5 mg$156In StockIn Stock
10 mg$248In StockIn Stock
25 mg$397In StockIn Stock
50 mg$569In StockIn Stock
100 mg$786In StockIn Stock
200 mg$1,090-In Stock
1 mL x 10 mM (in DMSO)$217In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Purity:98.55%
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Product Introduction

Bioactivity
Description
AGI-24512 is a potent inhibitor of methionine adenylyltransferase 2α (MAT2A) (IC50: 8 nM).AGI-24512 shows antiproliferative activity in MTAP-deficient cancer cells.AGI-24512 inhibits MAT2A, which causes DNA damage in MTAP, and is often used in conjunction with anticancer compounds in cancer research.
In vitro
MAT2A inhibitor AGI-24512 significantly blocked the proliferation of MTAP-deficient cancer cells in vitro[1].
In vivo
MAT2A inhibitor AGI-24512 showed poor bioavailability and short half-life in rats[2].
Chemical Properties
Molecular Weight400.47
FormulaC24H24N4O2
Cas No.2201066-53-5
SmilesCc1[nH]c2c(N3CCCCC3)c(nn2c(=O)c1-c1ccc(O)cc1)-c1ccccc1
Relative Density.1.33 g/cm3 (Predicted)
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 80 mg/mL (199.77 mM), Sonication is recommended.
H2O: < 0.1 mg/mL (insoluble)
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (8.24 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.4971 mL12.4853 mL24.9707 mL124.8533 mL
5 mM0.4994 mL2.4971 mL4.9941 mL24.9707 mL
10 mM0.2497 mL1.2485 mL2.4971 mL12.4853 mL
20 mM0.1249 mL0.6243 mL1.2485 mL6.2427 mL
50 mM0.0499 mL0.2497 mL0.4994 mL2.4971 mL
100 mM0.0250 mL0.1249 mL0.2497 mL1.2485 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
% DMSO
%
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

S-adenosylmethionine SynthetasePRMT5MTAPmethylthioadenosine phosphorylaseMethionine Adenosyltransferase (MAT)MATA2MAT2AHCT116DNA damage responseDNAantiproliferativeanticancerAGI-24512AGI24512AGI 24512
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