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Penitrem A
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Catalog No. T12403Cas No. 12627-35-9
Penitrem A is an indole-diterpenoid neurotoxic alkaloid produced by *Penicillium* species. As a selective BK channel antagonist, it exhibits antiproliferative and anti-invasive activities against various malignancies, and stimulates the spontaneous release of endogenous glutamate, GABA, and aspartate from cortical synaptosomes. It is commonly used to induce tremor models in animals.
Penitrem A
😃Good
Catalog No. T12403Cas No. 12627-35-9
Penitrem A is an indole-diterpenoid neurotoxic alkaloid produced by *Penicillium* species. As a selective BK channel antagonist, it exhibits antiproliferative and anti-invasive activities against various malignancies, and stimulates the spontaneous release of endogenous glutamate, GABA, and aspartate from cortical synaptosomes. It is commonly used to induce tremor models in animals.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $98 | 35 days | |
| 10 mg | $695 | 35 days |
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Chemical Properties
| Description | Penitrem A is an indole-diterpenoid neurotoxic alkaloid produced by *Penicillium* species. As a selective BK channel antagonist, it exhibits antiproliferative and anti-invasive activities against various malignancies, and stimulates the spontaneous release of endogenous glutamate, GABA, and aspartate from cortical synaptosomes. It is commonly used to induce tremor models in animals. |
| Molecular Weight | 634.2 |
| Formula | C37H44ClNO6 |
| Cas No. | 12627-35-9 |
| Relative Density. | 1.44 g/cm3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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