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PF-5212374
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Catalog No. T9901A-1262Cas No. 1169717-01-4
Alias TRU-015
PF-5212374 (TRU-015) is a CD20-directed small modular immunopharmaceutical (SMIP). Unlike traditional full-length antibodies, TRU-015 is a dimeric fusion protein comprising a single-chain Fv (scFv) binding domain coupled to the hinge and Fc regions of IgG1. It specifically binds to CD20 on the surface of B cells, activating Immunology/Inflammation-related signaling pathways to effectively mediate antibody-dependent cellular cytotoxicity (ADCC) and direct induction of apoptosis, resulting in the depletion of both normal and malignant B cells.
PF-5212374
PF-5212374
Copy Product Info🥰Excellent
Catalog No. T9901A-1262Alias TRU-015Cas No. 1169717-01-4
PF-5212374 (TRU-015) is a CD20-directed small modular immunopharmaceutical (SMIP). Unlike traditional full-length antibodies, TRU-015 is a dimeric fusion protein comprising a single-chain Fv (scFv) binding domain coupled to the hinge and Fc regions of IgG1. It specifically binds to CD20 on the surface of B cells, activating Immunology/Inflammation-related signaling pathways to effectively mediate antibody-dependent cellular cytotoxicity (ADCC) and direct induction of apoptosis, resulting in the depletion of both normal and malignant B cells.
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| Description | PF-5212374 (TRU-015) is a CD20-directed small modular immunopharmaceutical (SMIP). Unlike traditional full-length antibodies, TRU-015 is a dimeric fusion protein comprising a single-chain Fv (scFv) binding domain coupled to the hinge and Fc regions of IgG1. It specifically binds to CD20 on the surface of B cells, activating Immunology/Inflammation-related signaling pathways to effectively mediate antibody-dependent cellular cytotoxicity (ADCC) and direct induction of apoptosis, resulting in the depletion of both normal and malignant B cells. |
| In vitro | PF-5212374 (TRU-015) specifically binds human CD20. In Ramos or Daudi cells, it exhibits potent ADCC activity in the presence of NK cells. At nanomolar concentrations, it efficiently induces direct cell death and clears B cells in PBMC cultures [1]。 |
| In vivo | In pharmacological studies using non-human primate models (cynomolgus monkeys), systemic administration of PF-5212374 (at doses ranging from 0.1 to 10 mg/kg) results in rapid and sustained depletion of peripheral B cells. The treatment demonstrates effective lymphoid tissue penetration, leading to significant B-cell reduction in lymph nodes and spleen within complex physiological environments [1]. |
| Synonyms | TRU-015 |
| Reactivity | Human |
| Application | FACS Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Uniprot ID | |
| Target | CD20/MS4A1 |
| Cas No. | 1169717-01-4 |
| Isotype | IgG1 |
| Storage | store at low temperature | store at -20°C | Shipping with blue ice/Shipping at ambient temperature. |
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