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GLP-1(28-36)amide acetate

Name: GLP-1(28-36)amide acetate
Brand: TargetMol
SKU: T37890L
Price: 129 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T37890L

Alias GLP-1(28-36)amide acetate(1225021-13-5 Free base)

GLP-1(28-36)amide acetate inhibits mitochondrial permeability transition with antioxidant, anti-diabetic and cardioprotection activities.

GLP-1(28-36)amide acetate

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Purity: 99.9500%

Catalog No. T37890LAlias GLP-1(28-36)amide acetate(1225021-13-5 Free base)

GLP-1(28-36)amide acetate inhibits mitochondrial permeability transition with antioxidant, anti-diabetic and cardioprotection activities.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$129	-	In Stock
5 mg	$262	-	In Stock
10 mg	$442	-	In Stock
25 mg	$729	-	In Stock
50 mg	$987	-	In Stock
100 mg	$1,390	-	In Stock
500 mg	$2,780	-	In Stock
1 mL x 10 mM (in DMSO)	$551	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.9500%

Appearance:Solid

Color:White

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COA

Product Introduction

Bioactivity

Description	GLP-1(28-36)amide acetate inhibits mitochondrial permeability transition with antioxidant, anti-diabetic and cardioprotection activities.
In vitro	The plasma half-life of GLP-1(28-36)amide acetate is longer in human hepatocytes (24 min) than that in mouse hepatocytes (13 min). GLP-1(28-36)amide acetate (100 nM) on hepatocytes modulates mitochondrial oxidative metabolism including gluconeogenesis in mitochondria of hepatocytes[1].
In vivo	In high-fat diet-fed mice, GLP-1(28-36)amide acetate (18.5 nmol/kg) improved hepatic glucose disposal. In diet-induced obese mice, GLP-1(28-36)amide acetate (18.5 nmol/kg BW/day) diminishes the development of hepatic steatosis. In male C57BL6/J mice, administration of GLP-1(28-36)amide acetate for 20 min to, then isolated hearts underwent 30 min of global ischemia and 40 min of reperfusion, the recovery of left ventricular developed pressure is significantly great. In a β-cell injury diabetic mouse model, GLP-1(28-36)amide acetate (18 nmol/kg; i.p.) shows cytoprotective effect on pancreatic β cells by promoting proliferation and increasing mass[1].
Synonyms	GLP-1(28-36)amide acetate(1225021-13-5 Free base)

Chemical Properties

Molecular Weight	1148.4
Formula	C₅₆H₈₉N₁₅O₁₁
Smiles	CC(C[C@H](NC([C@@H](NC([C@@H](NC([C@@]([H])(NC([C@@H](N)CC1=CC=CC=C1)=O)[C@H](CC)C)=O)C)=O)CC2=CNC3=CC=CC=C32)=O)C(N[C@@H](C(C)C)C(N[C@@H](CCCCN)C(NCC(N[C@H](CCCNC(N)=N)C(N)=O)=O)=O)=O)=O)C.CC(O)=O
Sequence	Phe-Ile-Ala-Trp-Leu-Val-Lys-Gly-Arg
Sequence Short	FIAWLVKGR

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 11.49 mg/mL (10.01 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	0.8708 mL	4.3539 mL	8.7078 mL	43.5388 mL
5 mM	0.1742 mL	0.8708 mL	1.7416 mL	8.7078 mL
10 mM	0.0871 mL	0.4354 mL	0.8708 mL	4.3539 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc