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BMS-564929

Name: BMS-564929
Brand: TargetMol
SKU: T14675
Price: 149 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T14675Cas No. 627530-84-1

Alias BMS564929

BMS-564929 is a highly effective androgen receptor (AR) agonist that upregulates the expression and activity of lipogenic enzymes, reduces VAT content and lipid content, and downregulates the expression of acetyl-CoA carboxylase, FASN, and SCD.

BMS-564929

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Purity: 98.17%

Catalog No. T14675Alias BMS564929Cas No. 627530-84-1

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
2 mg	$149	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:98.17%

Appearance:Solid

Color:White

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COA

Product Introduction

Bioactivity

Description	BMS-564929 is a highly effective androgen receptor (AR) agonist that upregulates the expression and activity of lipogenic enzymes, reduces VAT content and lipid content, and downregulates the expression of acetyl-CoA carboxylase, FASN, and SCD.
Targets&IC50	AR:2.11 nM (Ki)
In vitro	BMS-564929 is a novel, highly effective and orally active non-steroidal tissue-selective androgen receptor (AR) modulator with Ki = 2.11 nM. The EC50 value of BMS-564929 in mouse myoblasts (C2C12) and rat PEC cell lines was 0.44 nM and 8.66 nM, respectively. [1]
In vivo	BMS-564929 (0.00001 - 10 mg/kg,14 days, gavage) is more effective than testosterone in stimulating the growth of the levator anal muscle and has a strong oral activity. [1]
Synonyms	BMS564929

Chemical Properties

Molecular Weight	305.72
Formula	C₁₄H₁₂ClN₃O₃
Cas No.	627530-84-1
Smiles	O=C1N(C(=O)N2[C@]1([C@H](O)CC2)[H])C3=C(C)C(Cl)=C(C#N)C=C3
Relative Density.	1.58 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 40 mg/mL (130.84 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.54 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2710 mL	16.3548 mL	32.7097 mL	163.5483 mL
5 mM	0.6542 mL	3.2710 mL	6.5419 mL	32.7097 mL
10 mM	0.3271 mL	1.6355 mL	3.2710 mL	16.3548 mL
20 mM	0.1635 mL	0.8177 mL	1.6355 mL	8.1774 mL
50 mM	0.0654 mL	0.3271 mL	0.6542 mL	3.2710 mL
100 mM	0.0327 mL	0.1635 mL	0.3271 mL	1.6355 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc