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SR10067

Name: SR10067
Brand: TargetMol
SKU: T12998
Price: 53 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T12998Cas No. 1380548-02-6

SR10067 is a potent, selective, and brain-penetrant agonist of Rev-Erbβ (IC50 = 160 nM) and Rev-Erbα (IC50 = 170 nM) with anxiolytic activity.

SR10067

🥰Excellent

Purity: 99.57%

Catalog No. T12998Cas No. 1380548-02-6

SR10067 is a potent, selective, and brain-penetrant agonist of Rev-Erbβ (IC50 = 160 nM) and Rev-Erbα (IC50 = 170 nM) with anxiolytic activity.

Pack Size	Price	Availability
1 mg	$53	In Stock
5 mg	$136	In Stock
10 mg	$218	In Stock
25 mg	$371	In Stock
50 mg	$536	In Stock
100 mg	$693	In Stock
200 mg	$953	In Stock
1 mL x 10 mM (in DMSO)	$147	In Stock

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Bulk & Custom

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:99.57%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	SR10067 is a potent, selective, and brain-penetrant agonist of Rev-Erbβ (IC50 = 160 nM) and Rev-Erbα (IC50 = 170 nM) with anxiolytic activity.
Targets&IC50	Rev-Erbα:170 nM , Rev-Erbβ:160 nM

Chemical Properties

Molecular Weight	465.58
Formula	C₃₁H₃₁NO₃
Cas No.	1380548-02-6
Smiles	CC(C)(C)Oc1ccc(OCC2Cc3ccccc3CN2C(=O)c2cccc3ccccc23)cc1
Relative Density.	1.159 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 65 mg/mL (139.61 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1479 mL	10.7393 mL	21.4786 mL	107.3929 mL
5 mM	0.4296 mL	2.1479 mL	4.2957 mL	21.4786 mL
10 mM	0.2148 mL	1.0739 mL	2.1479 mL	10.7393 mL
20 mM	0.1074 mL	0.5370 mL	1.0739 mL	5.3696 mL
50 mM	0.0430 mL	0.2148 mL	0.4296 mL	2.1479 mL
100 mM	0.0215 mL	0.1074 mL	0.2148 mL	1.0739 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc