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SR10067

Name: SR10067
Brand: TargetMol
SKU: T12998
Price: 40 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T12998Cas No. 1380548-02-6

SR10067 is a potent, selective, and brain-penetrant agonist of Rev-Erbβ (IC50 = 160 nM) and Rev-Erbα (IC50 = 170 nM) with anxiolytic activity.

SR10067

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Purity: 99.57%

Catalog No. T12998Cas No. 1380548-02-6

SR10067 is a potent, selective, and brain-penetrant agonist of Rev-Erbβ (IC50 = 160 nM) and Rev-Erbα (IC50 = 170 nM) with anxiolytic activity.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$40	In Stock	In Stock
5 mg	$81	In Stock	In Stock
10 mg	$123	In Stock	In Stock
25 mg	$259	In Stock	In Stock
50 mg	$386	In Stock	In Stock
100 mg	$567	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$89	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.57%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

SR10067 AI Summary

SR10067 shows agonist activity at Rev-erb alpha, repressing transcription at 10 µM and demonstrating an EC50 value of 140.0 nM. Measured by FRET and BMAL1-luciferase reporter assays, it consistently displays the same EC50 value of 140.0 nM. In C57Bl6 mice, it reaches a plasma concentration of 0.45 µM and achieves drug uptake in the brain at 1.5 µM. Furthermore, it exhibits a brain penetration rate of 333.0% after 2 hours post-administration..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	SR10067 is a potent, selective, and brain-penetrant agonist of Rev-Erbβ (IC50 = 160 nM) and Rev-Erbα (IC50 = 170 nM) with anxiolytic activity.
Targets&IC50	Rev-Erbβ:160 nM , Rev-Erbα:170 nM

Chemical Properties

Molecular Weight	465.58
Formula	C₃₁H₃₁NO₃
Cas No.	1380548-02-6
Smiles	CC(C)(C)Oc1ccc(OCC2Cc3ccccc3CN2C(=O)c2cccc3ccccc23)cc1
Relative Density.	1.159 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 65 mg/mL (139.61 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 2.5 mg/mL (5.37 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1479 mL	10.7393 mL	21.4786 mL	107.3929 mL
5 mM	0.4296 mL	2.1479 mL	4.2957 mL	21.4786 mL
10 mM	0.2148 mL	1.0739 mL	2.1479 mL	10.7393 mL
20 mM	0.1074 mL	0.5370 mL	1.0739 mL	5.3696 mL
50 mM	0.0430 mL	0.2148 mL	0.4296 mL	2.1479 mL
100 mM	0.0215 mL	0.1074 mL	0.2148 mL	1.0739 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc