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JNK

JNK signaling pathway is such a death pathway that control cell death. There are two main downstream signaling of JNK pathway: one is activation of death signaling such c-Jun, Fos and apoptosis signaling such as BIM, BAD, BAX protein or active P53 transcription, to promote cell apoptosis; the other is inhibition of the cell survival signaling such as STATs and CREB .

  • SR-3306
    T169271128096-91-2In house
    SR-3306 is a potent and highly inhibitor of brain penetrant JNK.
    • $44
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  • Anisomycin
    T675822862-76-6
    Anisomycin (NSC-76712) is an antibiotic isolated from various Streptomyces species. It interferes with protein and DNA synthesis by inhibiting peptidyl transferase or the 80S ribosome system.
    • $46
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  • Astragaloside IV
    T297384687-43-4
    Astragaloside IV (AS-IV), an active component isolated from Astragalus membranaceus, suppresses the activation of ERK1/2 and JNK, and downregulates matrix metalloproteases (MMP)-2, (MMP)-9 in MDA-MB-231 breast cancer cells. Astragaloside IV is a bioactive saponin first isolated from the dried plant roots of the genus Astragalus, which is used in traditional Chinese medicine.1 It dose-dependently inhibits human adenovirus type 3 (HAdV-3) in A549 cells (IC50 = 23 μM; LC50 = 865 μM).It inhibits replication of HAdV-3 and decreases HAdV-3-induced apoptosis. It has diverse protective effects for the cardiovascular, immune, digestive, and nervous systems. In particular, it reduces myocardial infarct size in dogs when administered prior to coronary ligation and reduces reperfusion arrhythmias in isolated rat hearts.
    • $32
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  • AS601245.2TFA (345987-15-7 free base)
    T8661345987-16-8
    AS601245.2TFA (345987-15-7 free base) (AS601245.2TFA) is a cell-permeable Inhibitor of JNK (IC50s of 150, 220, and 70 nM for hJNK1, hJNK2, and hJNK3, respectively).
    • $53
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  • SKLB-163
    T261931255099-06-9In house
    SKLB-163 acts by downregulating RhoGDI, activating JNK-1 signaling pathway and caspase-3, and reducing phosphorylated Akt and p44/42 MAPK.
    • $137
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  • Astragaloside
    T408217429-69-5
    Astragaloside, one of the main active ingredients in Astragalus membranaceus.
    • $50
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  • JIP-1 (153-163) acetate(438567-88-5 free base)
    TP1897L1
    JIP-1 (153-163) acetate(438567-88-5 free base) is a peptide inhibitor of c-Jun N-terminal kinase (JNK), based on residues 153-163 of JNK-interacting protein-1 (JIP-1). JIP-1 (153-163) acetate(438567-88-5 free base) binds to JNK with affinity in the micromolar range and minimally inhibits p38 and ERK.
    • $293
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  • Apelin-12 acetate
    T39823L
    Apelin-12 acetate possesses a high affinity to orphan receptor APJ receptor. Apelin-12 acetate inhibits the JNK and p38 MAPK signaling pathway of the apoptosis-related MAPKs family, thus offering protection to neurons.
    • $228
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  • JNK-IN-11
    T60534676594-38-0
    JNK-IN-11 is a potent JNK inhibitor that inhibits JNK1, JNK2, and JNK3 with IC50 values of 1.8, 21.4, and 2.2 µM, respectively.JNK-IN-11 can be used to study abnormalities in immune function.
    • $293
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  • D-JNKI-1 acetate
    T10937L
    D-JNKI-1 acetate (AM-111 acetate) is a highly potent and cell-permeable peptide inhibitor of JNK.
    • $167
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  • Epieriocalyxin A
    TN3967191545-24-1
    Epieriocalyxin A can suppress Caco-2 colon cancer cell growth. It could be a potential drug for colon cancer therapy in the future.
    • $216
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  • BSJ-04-122
    T731822513289-74-0In house
    BSJ-04-122 is a covalent MKK4/7 dual inhibitor that inhibits MKK4 and MKK7 with IC50 values of 4 nM and 181 nM, respectively.BSJ-04-122 can be used for cancer research.
    • $35
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  • Vacquinol-1
    T70085428-80-8In house
    Vacquinol-1 is an MKK4 activator, which rapidly and selectively induces glioma cell death.
    • $195
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  • TAK-715
    T6150303162-79-0
    TAK-715 is a p38 MAPK inhibitor for p38α.
    • $34
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  • SP600125
    T3109129-56-6
    SP600125 (JNK Inhibitor II) is a JNK inhibitor that inhibits JNK1, JNK2, and JNK3 (IC50=40/40/90 nM) with oral potency, reversibility, and ATP-competitive properties. SP600125 inhibits autophagy and induces apoptosis.
    • $41
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  • Isovitexin
    T6S137138953-85-4
    1. Isovitexin (Apigenin-6-C-Glucoside) exhibits a potential antioxidant activity. 2. Isovitexin shows a strong antihyperglycemic action, inhibits α-glucosidase in vivo.
    • $44
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  • JNK-IN-7
    T35981408064-71-0
    JNK-IN-7 (JNK inhibitor) is a selective JNK1/2/3 inhibitor (IC50: 1.54/1.99/0.75 nM). It can also inhibit phosphorylation of c-Jun, which is a substrate of JNK kinase.
    • $89
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  • Polyphyllin I
    T389550773-41-6
    Polyphyllin D induces apoptosis via the mitochondrial apoptotic pathway as evidenced by decreased Bcl-2 expression levels, disruption of MMP and increased Bax, cytochrome C, and cleaved-caspase-3 levels. Polyphyllin D has an anti-angiogenic effect. Polyphyllin D has toxicity in human RBCs as well as its underlying mechanism for the hemolysis and eryptosis/erythroptosis. Polyphyllin D has strong anticancer activity, can overcome drug resistance in R-HepG2 cells and elicit programmed cell death via mitochondrial dysfunction.
    • $52
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  • JNK-IN-8
    T26681410880-22-6
    JNK-IN-8 (JNK Inhibitor XVI) is an irreversible JNK1 2 4 inhibitor (IC50: 4.7 18.7 1 nM). The selectivity is higher 10-fold than MNK2, Fms and no inhibition of Met, c-Kit, PDGFRβ in A375 cell line.
    • $39
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  • Cornuside
    T4S2326131189-57-6
    1. Cornuside (Comuside) has immunomodulatory activity . 2. Cornuside suppresses expression levels of cytokine-induced proinflammatory and adhesion molecules in the human endothelial cells. 3. Cornuside can treat myocardial I/R and protect the liver from CCl4-induced acute hepatotoxicity, by reducing oxidative stress and suppressing inflammatory responses. 4. Cornuside has anti-inflammatory activity by downregulations of iNOS and COX-2 due to NF-κB inhibition as well as the negative regulation of ERK1/2, p38, and JNK1/2 phosphorylations in RAW 264.7 cells. 5. Cornuside has protective potential against cerebral ischemic injury, may be due to the suppression of intracellular Ca(2+) elevation and caspase-3 activity, and improvements in mitochondrial energy metabolism and antioxidant properties.
    • $97
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  • Samidin
    TN4938477-33-8
    Samidin has anti-inflammatory properties through suppression of NF-κB and AP-1-mediated-genes in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells.
    • $480
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  • Panaxydol
    TN203972800-72-7
    Panaxydol has anti-cancer activity, can inhibit the growth and apoptosis of cancer cells, the signaling mechanisms involve a [Ca(2+)](i) increase, JNK and p38 MAPK activation, cAMP, MAP kinase and ROS generation through NADPH oxidase and mitochondria.
    • $220
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  • Goshonoside F5
    TN416290851-28-8
    Goshonoside F5 has anti-inflammatory activity, it significantly inhibits the pro-inflammatory response induced by LPS, both in vitro and in vivo.
    • $380
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  • Excisanin A
    TN404678536-37-5
    ExcisaninA may be a potent inhibitor of AKT signaling pathway in tumor cells, it can inhibit invasion by suppressing MMP-2 and MMP-9 expression, it may be a potential anti-metastatic chemotherapeutic agent for the treatment of breast cancer. Excisanin A shows comparable inhibitory effects on the LPS-induced production of NO and PGE2, and activation of NF-kappaB without affecting cell viability.Excisanin A induces apoptosis in colon cancer cell line SW620 as determined by Annexin V staining, the cleavage of caspase-3 and the proteolytic degradation of poly (ADP-ribose) polymerase (PARP).
    • $980
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  • Lappaol C
    TN441064855-00-1
    Lappaol C has antioxidant and antiaging properties, it may promote the C. elegans longevity and stress resistance through a JNK-1-DAF-16 cascade. Lappaol C also has potential chemosensitizing activity, it may be candidates for developing novel adjuvant an
    • $730
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  • Isoangustone A
    TN4263129280-34-8
    Isoangustone A has antitumor activity, it can induce G1 cycle arrest in DU145 human prostate and 4T1 murine mammary cancer cells, it inhibits cell proliferation by targeting PI3K, MKK4, and MKK7 in human melanoma. Isoangustone A dampens mesangial sclerosis associated with inflammation in response to high glucose through hindering TGF-β and NF-κB signaling. Isoangustone A also shows strong ferric reducing activities and effectively scavenged DPPH, ABTS(+), and singlet oxygen radicals.
    • $540
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  • Pinusolide
    TL001431685-80-0
    Pinusolide is a platelet activating factor ( PAF) antagonist, it may prove of therapeutic value in the treatment of hypotension, it has antileukemic potential, and could be used to treat neurodegenerative diseases. Pinusolide attenuates blockade of insulin signaling by enhancing IRS-1 tyrosine phosphorylation by the activating the AMPK pathway, indicates the targeting of AMPK represents a new therapeutic strategy for hyperglycemia-induced insulin resistance and type 2 diabetes.
    • $310
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  • IQ-3
    T8477312538-03-7
    IQ3 is a selective inhibitor of JNK3(JNK3, JNK1 and JNK2 with Kd of 66 nM, 240 nM and 290 nM, respectively). IQ 3 inhibits NF-κB/AP1 transcriptional activity in THP1-Blue cells with IC50 of 1.4 μM, also inhibits TNF-α and IL-6 production in vitro.
    • $34
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  • Dehydroglyasperin C
    TN3806199331-35-6
    Dehydroglyasperin C is a potent NAD(P)H:oxidoquinone reductase (NQO1) and phase 2 enzyme inducer. Dehydroglyasperin C possesses potent antioxidant, cancer chemopreventive, and neuroprotective activities, it has protective effects against chronic diseases
    • $871
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  • Isocryptotanshinone
    TN177522550-15-8
    Isocryptotanshinone inhibits protein tyrosine phosphatase 1B (PTP1B) activity with 50% inhibitory concentration values of 56.1±6.3 μM, PTP1B acts as a negative regulator of insulin signaling, and selective inhibition of PTP1B has served as a potential drug target for the treatment of type 2 diabetes.
    • $790
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  • Shizukaol B
    TN5011142279-40-1
    Shizukaol B exerts anti-inflammatory effects in LPS-activated microglia partly by modulating JNK-AP-1 signaling pathway; it also shows significant anti-neuroinflammatory effects by inhibiting nitric-oxide (NO) production in lipopolysaccharide (LPS)-stimul
    • $317
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  • Grasshopper ketone
    TN538741703-38-2
    Grasshopper ketone, isolated from the brown alga Sargassum, is a potent inhibitor of LPS-induced NO production in RAW 264.7 cells and induces anti-inflammatory effects by inhibiting MAPK (ERK, JNK and p38) and NF-κB p65 phosphorylation.
    • $1,698
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  • Manassantin A
    TN448988497-87-4
    Manassantin A is a high potent HIF-1 inhibitor, it protects the gastric mucosa from ethanol-induced acute gastric injury, and suggest that these protective effects might be associated with COX/PGE2 stimulation, inhibition of iNOS production and NF-κB act
    • $1,280
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  • JNK-IN-12
    T79296
    JNK-IN-12 (compound P2) is a mitochondrial-targeted JNK inhibitor with an IC50 value of 66.3 nM, comprising a mitochondrial-specific cell-penetrating peptide linked to SP600125, a selective JNK inhibitor. It selectively impedes mitochondrial JNK phosphorylation without inhibiting nuclear JNK signaling and has been shown to ameliorate Parkinson's disease (PD) symptoms in both in vitro and in vivo studies [1].
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  • Physalin A
    TN477423027-91-0
    Physalin A exerts anti-tumor activity in non-small cell lung cancer cell lines by suppressing JAK/STAT3 signaling, it inhibits androgen-independent prostate cancer cell growth through activation of cell apoptosis and downregulation of androgen receptor ex
    • $998
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  • OVA-E1 peptide TFA
    T386651262750-80-0
    OVA-E1 peptide TFA activates the p38 and JNK cascades similarly in mutant and wild-type thymocytes.
    • $154
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  • Salicortin
    T128281887055-63-1
    Salicortin is a phenolic glycoside isolated from many plants such as Populus and Salix species, has anti-adipogenic, anti-amnesic, and immune-modulatory activity.
    • $1,520
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  • Lucideric acid A
    TN187995311-94-7
    Lucideric acid A (Lucidenic acid A) is a modulator of JNK and p38 and enhances LPS-induced immune responses in monocytic THP-1 cells possibly via the modulation of p38 and JNK/MAPKs activation.
    • $39
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  • Ganoderic acid X
    TN410786377-53-9
    Ganoderic acid X is a potential Mdm2 inhibitor(K(i) = 16nM). It is a potential anticancer drug, inhibits topoisomerases and induces apoptosis of cancer cells.
    • $290
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  • Kobophenol A
    TN4394124027-58-3
    Kobophenol A has antimicrobial, and anti-inflammatory activities, it might be a candidate for treatment of inflammatory bone diseases relevant to osteoblast cell death. Kobophenol A inhibits AChE activity in a dose-dependent manner, and the IC50 value is
    • $523
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  • D-JNKI-1
    T109371445179-97-4
    D-JNKI-1 (AM-111) is a highly effective and cell-permeable peptide inhibitor.
    • $1,140
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  • Capillarisin
    TN358756365-38-9
    Capillarisin is a novel blocker of STAT3 activation and thus may have a potential in negative regulation of growth, metastasis, and chemoresistance of tumor cells, it inhibits cancer cell growth of osteosarcoma cells by inducing apoptosis accompanied with
    • $2,169
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  • Isopedicin
    TN43174431-42-9
    Isopedicin has anti-inflammatory functions, it inhibits the O(2)(*)(-) production in human neutrophils by an elevation of cellular cAMP and activation of PKA through its inhibition of cAMP-specific PDE.
    • $659
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  • d-Epigalbacin
    TN712184709-25-1
    d-Epigalbacin ((-)-Zuonin A) is a naturally occurring lignin. d-Epigalbacin is a potent, selective JNKs inhibitor, with IC50s of 1.7 μM, 2.9 μM and 1.74 μM for JNK1, JNK2 and JNK3, respectively.
    • $129
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  • Lappaol F
    TN441169394-17-8
    1. Lappaol F has antioxidant and antiaging properties, it may promote the C. elegans longevity and stress resistance through a JNK-1-DAF-16 cascade.
    2. Lappaol F has potential chemosensitizing activity, it may be candidates for developing novel adju
    • $361
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  • Licopyranocoumarin
    TN4435117038-80-9
    Licopyranocoumarin could as a potent neuroprotective drug via markedly blocked MPP+-induced neuronal PC12D cell death and disappearance of mitochondrial membrane potential, which were mediated by JNK.
    • $760
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  • Desoxo-narchinol A
    TN383953859-06-6
    Desoxo-narchinol A exhibits protective effects against LPS-induced endotoxin shock and inflammation through p38 deactivation, it shows inhibitory activity against LPS-induced NO production. Desoxo-narchinol A shows cytotoxic activity against P-388 cells.
    • $420
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  • 3,5-Dicaffeoyl-epi-quinic acid
    TN2895879305-14-3
    3,5-Dicaffeoyl-epi-quinic acid shows anti-inflammatory activity, it may improve mast cell-mediated inflammatory diseases.
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  • (E)-Ferulic acid methyl ester
    T3S000622329-76-6
    (E)-Ferulic acid methyl ester (Methyl (E)-ferulate) is a possible inhibitor of the mitogen activated phosphor kinase pathway, it could be a potential anti-inflammatory agent isolated for the first time in medicinal plant S. tuberosa. (E)-Ferulic acid methyl ester has promising anthelmintic activity against Haemonchus contortus.
    • $50
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  • Juglanin
    TQ00895041-67-8
    Juglanin is a JNK activator. Juglanin with inflammation and anti-tumor activities. It can induce apoptosis and autophagy on human breast cancer cells.
    • $119
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