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Coumetarol

Name: Coumetarol
Brand: TargetMol
SKU: T10867
Price: 149 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T10867Cas No. 4366-18-1

Alias Ph 137, Dicumoxane

Coumetarol (Dicumoxane) is a vitamin K antagonist and an oral anticoagulant that can be used to study arterial thrombotic occlusion.

Coumetarol

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Purity: 99.01%

Catalog No. T10867Alias Ph 137, DicumoxaneCas No. 4366-18-1

Coumetarol (Dicumoxane) is a vitamin K antagonist and an oral anticoagulant that can be used to study arterial thrombotic occlusion.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$49	-	In Stock
5 mg	Preferential	-	In Stock
1 mL x 10 mM (in DMSO)	$149	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99.01%

Appearance:Solid

Color:White

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COA

Product Introduction

Bioactivity

Description	Coumetarol (Dicumoxane) is a vitamin K antagonist and an oral anticoagulant that can be used to study arterial thrombotic occlusion.
In vitro	The vitamin K antagonist Coumetarol (Dicumoxane) is effective in both models after oral treatment but inhibits thrombus formation more strongly in the arterio-venous shunt model. Treatment with Coumetarol in a dose of 25 mg/kg p.o. twice daily for 2 days results in a significant reduction in thrombus weight by 50% in the venous stasis model and by 75% in the arterio-venous shunt model. In both experiments, the coagulation time as measured by the Thrombotest is prolonged to the same extent.
In vivo	The vitamin K antagonist Coumetarol showed efficacy in both models after oral treatment, particularly demonstrating stronger thrombotic inhibition in the arteriolar junction model. Coumetarol was administered orally at a therapeutic dose of 25 mg/kg. Twice-daily administration for two consecutive days resulted in a significant 50% reduction in thrombus weight in the venous pause model and a significant 75% reduction in the arterial cleft shunt model. [1]
Synonyms	Ph 137, Dicumoxane

Chemical Properties

Molecular Weight	380.35
Formula	C₂₁H₁₆O₇
Cas No.	4366-18-1
Smiles	O=C1OC=2C=CC=CC2C(O)=C1C(C=3C(=O)OC=4C=CC=CC4C3O)COC
Relative Density.	1.514 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 180 mg/mL (473.25 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (10.52 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6292 mL	13.1458 mL	26.2916 mL	131.4579 mL
5 mM	0.5258 mL	2.6292 mL	5.2583 mL	26.2916 mL
10 mM	0.2629 mL	1.3146 mL	2.6292 mL	13.1458 mL
20 mM	0.1315 mL	0.6573 mL	1.3146 mL	6.5729 mL
50 mM	0.0526 mL	0.2629 mL	0.5258 mL	2.6292 mL
100 mM	0.0263 mL	0.1315 mL	0.2629 mL	1.3146 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc