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4-Methylherniarin (Synonyms: 7-Methoxy-4-methylcoumarin)

Name: 4-Methylherniarin
Brand: TargetMol
SKU: T2785
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T2785 Copy Product Info

Purity: 98.05%

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4-Methylherniarin (7-Methoxy-4-methylcoumarin) is a coumarin derivative and fluorescent label that exhibits significant activity against B. subtilis.

4-Methylherniarin

Copy Product Info

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Catalog No. T2785

Synonyms 7-Methoxy-4-methylcoumarin

4-Methylherniarin (7-Methoxy-4-methylcoumarin) is a coumarin derivative and fluorescent label that exhibits significant activity against B. subtilis.

Cas No. 2555-28-4

Pack Size	Price	USA Stock	Global Stock	Quantity
500 mg	$30	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:98.05%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

4-Methylherniarin AI Summary

4-Methylherniarin exhibits a variety of bioactivities and pharmacological properties. It inhibits rat lens aldose reductase by 21.0% at 0.1 mM concentration. The compound induces apoptosis in human U937 cells at 250 µM after 24 hours with 4.0% activity, and shows cytotoxicity with a CC50 greater than 2,000,000 nM after 48 hours. It also inhibits the growth of these cells in the [3H]thymidine incorporation assay with an IC50 greater than 2,000,000 nM. 4-Methylherniarin is an inhibitor of various enzymes: 1. HSD17B4 with an IC50 of 31,622.8 nM, 2. JMJD2E with an IC50 of 25,118.9 nM, 3. ALDH1A1 with an IC50 of 28,183.8 nM, 4. HPGD with an IC50 of 14,125.4 nM, 5. TrxR1 with an IC50 of 70,794.6 nM, 6. Induces DNA re-replication in SW480 colon adenocarcinoma cells at 183.6 nM. In transporter assays, 4-Methylherniarin inhibits sodium fluorescein uptake in OATP1B1- and OATP1B3-transfected CHO cells by 109.18% and 127.11%, respectively, at 10 µM. The compound also shows antiasthmatic activity by reversing carbachol-induced contraction in Wistar rat tracheal rings, achieving a maximum effect (Emax) of 100% with an EC50 of 230,000 nM. The compound's lipophilicity is indicated by a log P value of 2.46. It inhibits ALDH3A1 by 36.4%, ALDH1A1 by 80.2%, and ALDH2 by 94.8%. Additionally, 4-Methylherniarin exhibits antiviral activity against Infectious hematopoietic necrosis virus glycoprotein G with a 2.13% inhibition rate at 25 µM..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	4-Methylherniarin (7-Methoxy-4-methylcoumarin) is a coumarin derivative and fluorescent label that exhibits significant activity against B. subtilis.
Targets&IC50	B. subtilis:11.76 μg/ml (IC50), S. sonnei:13.47 μg/ml (IC50)
Synonyms	7-Methoxy-4-methylcoumarin

Chemical Properties

Molecular Weight	190.2
Formula	C₁₁H₁₀O₃
Cas No.	2555-28-4
Smiles	COC1=CC=C2C(C)=CC(=O)OC2=C1
Relative Density.	1.195g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 11 mg/mL (57.83 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (10.52 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	5.2576 mL	26.2881 mL	52.5762 mL	262.8812 mL
5 mM	1.0515 mL	5.2576 mL	10.5152 mL	52.5762 mL
10 mM	0.5258 mL	2.6288 mL	5.2576 mL	26.2881 mL
20 mM	0.2629 mL	1.3144 mL	2.6288 mL	13.1441 mL
50 mM	0.1052 mL	0.5258 mL	1.0515 mL	5.2576 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc