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Tiludronate disodium

Name: Tiludronate disodium
Brand: TargetMol
SKU: T13159
Price: 73 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T13159Cas No. 149845-07-8

Alias Tiludronic Acid disodium, Tiludronic acid disodium

Tiludronate disodium (Tiludronic acid disodium) is an osteoclast vacuolar H(+)-ATPase inhibitor with antiresorptive and anti-inflammatory properties. Tiludronate disodium can be used in studies about metabolic bone disorders.

Tiludronate disodium

🥰Excellent

Catalog No. T13159Alias Tiludronic Acid disodium, Tiludronic acid disodiumCas No. 149845-07-8

Pack Size	Price	Availability
5 mg	$73	In Stock
10 mg	$117	In Stock
25 mg	$198	In Stock
50 mg	$297	In Stock
100 mg	$441	In Stock
500 mg	$888	In Stock

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Bulk & Custom

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:>99.99%

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	Tiludronate disodium (Tiludronic acid disodium) is an osteoclast vacuolar H(+)-ATPase inhibitor with antiresorptive and anti-inflammatory properties. Tiludronate disodium can be used in studies about metabolic bone disorders.
In vitro	Tiludronate displays potent inhibitory against proton transport in yeast microsomal preparations with an IC50 of 3.5 μM and inhibits the activity of purified yeast V-ATPase. Tiludronate inhibits proton transport with IC50s of 1.1 mM and 466 nM in kidney-derived vesicles and vesicles derived from osteoclasts[3].
In vivo	Tiludronate dose-dependently inhibits the resorption of bones. Tiludronate reduces the secrete proton of mature osteoclasts into the resorption space and favors the detachment of mature osteoclasts from the bone matrix. Oral administration of Tiludronate (5-200 mg/kg) prevents the decrease in the skeletal mass in the castrated male rat model[3].
Synonyms	Tiludronic Acid disodium, Tiludronic acid disodium

Chemical Properties

Molecular Weight	362.57
Formula	C₇H₇ClNa₂O₆P₂S
Cas No.	149845-07-8
Smiles	[Na+].[Na+].OP([O-])(=O)C(Sc1ccc(Cl)cc1)P(O)([O-])=O
Relative Density.	no data available
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 56.2 mg/mL (155.1 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	2.7581 mL	13.7904 mL	27.5809 mL	137.9044 mL
5 mM	0.5516 mL	2.7581 mL	5.5162 mL	27.5809 mL
10 mM	0.2758 mL	1.3790 mL	2.7581 mL	13.7904 mL
20 mM	0.1379 mL	0.6895 mL	1.3790 mL	6.8952 mL
50 mM	0.0552 mL	0.2758 mL	0.5516 mL	2.7581 mL
100 mM	0.0276 mL	0.1379 mL	0.2758 mL	1.3790 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc