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Hydrocinnamic acid

Name: Hydrocinnamic acid
Brand: TargetMol
SKU: T3731
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3731Cas No. 501-52-0

Alias 3-Phenylpropionic acid, 3-Phenylpropanoic acid, 3-Phenyl-n-propionic acid

Hydrocinnamic acid is an inter-root compound with growth-regulating activity.

Hydrocinnamic acid

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Purity: 99.97%

Catalog No. T3731Alias 3-Phenylpropionic acid, 3-Phenylpropanoic acid, 3-Phenyl-n-propionic acidCas No. 501-52-0

Hydrocinnamic acid is an inter-root compound with growth-regulating activity.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
5 g	$31	-	In Stock
10 g	$44	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.97%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Hydrocinnamic acid AI Summary

Hydrocinnamic acid has been evaluated for its bioactivity with various assays indicating several notable properties. It exhibits a binding energy of 5.5 kCal mol^-1, calculated using the equation deltaG obsd = -RT ln KD, suggesting strong potential for binding interactions. The compound also shows inhibition of melanogenesis and melanin production in theophylline-stimulated mouse B16-4A5 cells, demonstrating dose-dependent activity with increased inhibition at higher concentrations. Additionally, it inhibits mushroom tyrosinase, indicating possible applications as a depigmenting agent for skin pigmentation regulation. Further bioactivity assays reveal its inhibitory activity against chymotrypsin (log1/Ki value of 2.79) and its weak inhibition of dehydrogenase activity of recombinant CtBP2 enzyme with an IC50 value greater than 300,000 nM. It also shows antioxidant activity with an ORAC-FL assay result of 0.86 equivalents, and a 15.0% inhibition bioactivity in human TAS2R39 assays in HEK293 cells. Pharmacokinetic and physicochemical profiling provides additional insights: - Dissociation constant, pKa = 4.64 at 100 µM - Percentage unbound in human plasma, Fu = 0.095 at 5 µM after 6 hrs - Kinetic solubility in aqueous phosphate buffer = 110690.0 nM at pH 7.4 at 200 µM after 24 hrs - 1-Octanol-aqueous buffer distribution coefficient, LogD = -0.49 at pH 7.4 - Effective permeability, Peff = 1.66 µcm/s at 200 µM after 5 hrs - Membrane retention, R% = -7.0% at pH 7.4 - Apparent permeability, logPapp = -5.79 at pH 7.4 Lastly, Hydrocinnamic acid binds to the human recombinant Keap1 Kelch domain, evidenced by changes in melting temperature, dissociation constants via surface plasmon resonance, and saturation transfer difference-NMR analysis. These diverse bioactivities indicate its potential for various biomedical applications..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Hydrocinnamic acid is an inter-root compound with growth-regulating activity.
Synonyms	3-Phenylpropionic acid, 3-Phenylpropanoic acid, 3-Phenyl-n-propionic acid

Chemical Properties

Molecular Weight	150.17
Formula	C₉H₁₀O₂
Cas No.	501-52-0
Smiles	OC(=O)CCC1=CC=CC=C1
Relative Density.	0.607 g/cm3. Temperature:26.4 °C.;0.743 g/cm3. Temperature:26.4 °C.

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 10 mg/mL (66.59 mM), Sonication is recommended.

DMSO: 100 mg/mL (665.91 mM), Sonication is recommended.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	6.6591 mL	33.2956 mL	66.5912 mL	332.9560 mL
5 mM	1.3318 mL	6.6591 mL	13.3182 mL	66.5912 mL
10 mM	0.6659 mL	3.3296 mL	6.6591 mL	33.2956 mL
20 mM	0.3330 mL	1.6648 mL	3.3296 mL	16.6478 mL
50 mM	0.1332 mL	0.6659 mL	1.3318 mL	6.6591 mL

DMSO

	1mg	5mg	10mg	50mg
100 mM	0.0666 mL	0.3330 mL	0.6659 mL	3.3296 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc