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MCPA
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Catalog No. T20701Cas No. 94-74-6
Alias U 46 M-Fluid, Raphone, NSC-2351, NSC2351, NSC 2351, Krezone
MCPA(Krezone) is a highly effective phenoxy herbicide. Use of MCPA would have impacts on nearby water and soil resources.
MCPA
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Purity: 97.42%
Catalog No. T20701Alias U 46 M-Fluid, Raphone, NSC-2351, NSC2351, NSC 2351, KrezoneCas No. 94-74-6
MCPA(Krezone) is a highly effective phenoxy herbicide. Use of MCPA would have impacts on nearby water and soil resources.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 5 g | $55 | - | In Stock | |
| 10 g | $80 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $29 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Batch Information
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Purity:97.42%
Appearance:Solid
Color:White
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Product Introduction
MCPA AI Summary
MCPA demonstrates a diverse range of bioactivities and pharmacokinetic properties. It shows high Ki values (>10000.0 nM) indicating low bioactivity in displacing [3H]PG2 from the human CRTh2 receptor and binding affinity at the prostanoid DP receptor. However, it exhibits potent modulatory and inhibitory effects in various assays, such as:
1. Lipid storage modulation in Drosophila S3 cells (potency of 23.1 nM).
2. Cell-membrane permeable IMPase inhibition (79.4 nM).
3. Small molecule agonist activity towards the estrogen receptor alpha signaling pathway (25118.9 nM).
4. Inhibition of HP1-beta chromodomain interaction with methylated histone tails (50118.7 nM).
5. Inhibition of firefly luciferase (30131.3 nM).
6. Agonistic effects on the vitamin D receptor signaling pathway (1.6 nM).
7. Induction of DNA re-replication in MCF 10a normal breast cells (103.2 nM) and SW480 colon adenocarcinoma cells (51.7 nM).
8. Influence on the antioxidant response element (ARE) signaling pathway (68589.6 nM).
9. Inhibition of TDP-43 (7943.3 nM).
Additionally, MCPA demonstrates acute toxicity with an LD50 value of 962.0 mg/kg in orally dosed Wistar rats. Pharmacokinetic studies show varying half-life values in different species, with 11.0 hours in human plasma, 6.0 hours in rat plasma, and 63.0 hours in dog plasma at a dosage of 5 mg/kg, indicating differences in metabolism and elimination rates across species..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | MCPA(Krezone) is a highly effective phenoxy herbicide. Use of MCPA would have impacts on nearby water and soil resources. |
| Synonyms | U 46 M-Fluid, Raphone, NSC-2351, NSC2351, NSC 2351, Krezone |
| Molecular Weight | 200.62 |
| Formula | C9H9ClO3 |
| Cas No. | 94-74-6 |
| Smiles | O(CC(O)=O)C1=C(C)C=C(Cl)C=C1 |
| Relative Density. | 1.313 g/cm3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 45 mg/mL (224.3 mM), Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
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