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MMP-2/MMP-9 Inhibitor I

Catalog No. T21512 CAS 193807-58-8

MMP-2/MMP-9-IN-1 is a potent, highly selective and orally bioavailable inhibitor of type IV collagenases (MMP-9 and MMP-2) with an IC50 of 0.24 and 0.3 1 μM for MMP-9 and MMP-2, respectively. activity, which can be used to study cancer.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

MMP-2/MMP-9 Inhibitor I Chemical Structure

MMP-2/MMP-9 Inhibitor I, CAS 193807-58-8

Pack Size	Availability	Price/USD
1 mg	In stock	$ 54.00
5 mg	In stock	$ 128.00
10 mg	In stock	$ 197.00
25 mg	In stock	$ 396.00
50 mg	In stock	$ 655.00
100 mg	In stock	$ 987.00
500 mg	In stock	$ 1,980.00
1 mL * 10 mM (in DMSO)	In stock	$ 172.00

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Purity: 99.74%

Biological Description

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Description	MMP-2/MMP-9-IN-1 is a potent, highly selective and orally bioavailable inhibitor of type IV collagenases (MMP-9 and MMP-2) with an IC50 of 0.24 and 0.3 1 μM for MMP-9 and MMP-2, respectively. activity, which can be used to study cancer.
Targets&IC50	MMP9:0.24 μM, MMP2:0.31 μM
In vitro	MMP-2/MMP-9 inhibitor I was identified as a potent inhibitor of matrix metalloproteinase-2 (MMP-2) and MMP-9 with IC50 values of 310 and 240 nM, respectively. MMP-2/MMP-9 inhibitor I acted by binding zinc at the active site of these MMPs. MMP-2/MMP-9 inhibitor I was found to be able to block MMP-2/MMP-9-dependent invasion in cell culture model.[1]
In vivo	Both hydroxamic acid and carboxylic acid analogs of MMP-2/MMP-9 inhibitor I were evaluated for their inhibitory activities in animal cancer models. Results showed that lung colonization of Lewis lung carcinoma cells was suppressed by these inhibitors significantly. In addition, antitumor activity was also observed in the human lung cancer model. Ma44 cells growed as a solid tumor on the peritoneum after being implanted ip, and mice bearing Ma44 eventually died within 3 to 4 weeks. Daily oral administration of compound 5l led to prolonged survival of Ma44-bearing mice.[1]

Molecular Weight	381.44
Formula	C21H19NO4S
CAS No.	193807-58-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 180.0 mg/mL (471.9 mM)

References and Literature

1. Tamura Y, et al. Highly selective and orally active inhibitors of type IV collagenase (MMP-9 and MMP-2): N-sulfonylamino acid derivatives. J Med Chem. 1998;41(4):640-649.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Anti-Cancer Active Compound Library Highly Selective Inhibitor Library Anti-Cancer Compound Library Bioactive Compound Library Bioactive Compounds Library Max Protease Inhibitor Library

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

MMP-2/MMP-9 Inhibitor I 193807-58-8 Proteases/Proteasome MMP MMP 2/MMP 9 Inhibitor I MMP2/MMP9 Inhibitor I inhibitor inhibit

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