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Remogliflozin etabonate

Name: Remogliflozin etabonate
Brand: TargetMol
SKU: T34286
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T34286Cas No. 442201-24-3

Alias GSK-189075A, GSK189075A, GSK-189075, GSK189075, GSK 189075A, GSK 189075

Remogliflozin etabonate (GSK189075A) is a prodrug of regaliflozin and an inhibitor SGLT2 with Ki values of 1.95, 2.14, 8.57, and 43.1μM for hSGLT2, rSGLT2, rSGLT1, and hSGLT1, respectively.

Remogliflozin etabonate

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Purity: 98.98%

Catalog No. T34286Alias GSK-189075A, GSK189075A, GSK-189075, GSK189075, GSK 189075A, GSK 189075Cas No. 442201-24-3

Remogliflozin etabonate (GSK189075A) is a prodrug of regaliflozin and an inhibitor SGLT2 with Ki values of 1.95, 2.14, 8.57, and 43.1μM for hSGLT2, rSGLT2, rSGLT1, and hSGLT1, respectively.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$30	-	In Stock
5 mg	$48	-	In Stock
10 mg	$88	-	In Stock
25 mg	$167	-	In Stock
50 mg	$257	-	In Stock
100 mg	$358	-	In Stock
200 mg	$497	-	In Stock
1 mL x 10 mM (in DMSO)	$56	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.98%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Remogliflozin etabonate (GSK189075A) is a prodrug of regaliflozin and an inhibitor SGLT2 with Ki values of 1.95, 2.14, 8.57, and 43.1μM for hSGLT2, rSGLT2, rSGLT1, and hSGLT1, respectively.
Targets&IC50	SGLT2 (human):1.95 μM (Ki), SGLT1 (rat):8.57 μM (Ki), SGLT2 (rat):2.14 μM (Ki), SGLT1 (human):43.1 μM (Ki)
In vivo	Oral administration of Remogliflozin etabonate (10-30 mg/kg) dose-dependently reduces the levels of FPG and GHb. Oral administration of Remogliflozin etabonate (3-30 mg/kg) dose-dependently increases urine volume and urinary glucose excretion[2].
Synonyms	GSK-189075A, GSK189075A, GSK-189075, GSK189075, GSK 189075A, GSK 189075

Chemical Properties

Molecular Weight	522.59
Formula	C₂₆H₃₈N₂O₉
Cas No.	442201-24-3
Smiles	CCOC(=O)OC[C@H]1O[C@@H](Oc2nn(C(C)C)c(C)c2Cc2ccc(OC(C)C)cc2)[C@H](O)[C@@H](O)[C@@H]1O
Relative Density.	1.31 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 90 mg/mL (172.22 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (6.31 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9135 mL	9.5677 mL	19.1355 mL	95.6773 mL
5 mM	0.3827 mL	1.9135 mL	3.8271 mL	19.1355 mL
10 mM	0.1914 mL	0.9568 mL	1.9135 mL	9.5677 mL
20 mM	0.0957 mL	0.4784 mL	0.9568 mL	4.7839 mL
50 mM	0.0383 mL	0.1914 mL	0.3827 mL	1.9135 mL
100 mM	0.0191 mL	0.0957 mL	0.1914 mL	0.9568 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc