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LSD1-IN-24

Catalog No. T67871 CAS 4734-59-2

LSD1-IN-24 is a selective and potent LSD1 inhibitor with an IC50 value of 0.247 μM.LSD1-IN-24 induces PD-L1 expression and enhances the T cell killing response, and can be used in cancer-related diseases.

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LSD1-IN-24, CAS 4734-59-2

Pack Size	Availability	Price/USD
1 mg	In stock	$ 73.00
5 mg	In stock	$ 178.00
10 mg	In stock	$ 289.00
25 mg	In stock	$ 578.00
50 mg	In stock	$ 925.00
100 mg	In stock	$ 1,230.00
500 mg	In stock	$ 2,490.00
1 mL * 10 mM (in DMSO)	In stock	$ 195.00

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Purity: 99.53%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	LSD1-IN-24 is a selective and potent LSD1 inhibitor with an IC50 value of 0.247 μM.LSD1-IN-24 induces PD-L1 expression and enhances the T cell killing response, and can be used in cancer-related diseases.
In vitro	LSD1-IN-24 (compound 3S) (0-20 μM, 5 days) can dose-dependently reduce PD-L1 levels in an LSD1-dependent manner and enhance T-cell cytotoxicity against BGC-823 cells. It does not affect the proliferation of BGC-823 and MFC cells. Additionally, it can dose-dependently protect H3K4me1/2 from demethylation but cannot protect H3K4me3[1].
In vivo	In a subcutaneous tumor model containing MFC cells, LSD1-IN-24 (compound 3S) (0-50 mg/kg, oral gavage; daily for 2 weeks) dose-dependently inhibits the in vivo growth of MFC cells. The tumor weight significantly decreases, Ki67 expression in tumor tissues markedly decreases, and there is no apparent toxicity observed in mice[1].

Molecular Weight	312.43
Formula	C18H20N2OS
CAS No.	4734-59-2

Storage

store at low temperature

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (160.04 mM)

References and Literature

1. Xing-Jie Dai, et al. Phenothiazine-Based LSD1 Inhibitor Promotes T-Cell Killing Response of Gastric Cancer Cells. J Med Chem. 2023 Mar 23;66(6):3896-3916.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Immunology/Inflammation Compound Library

Related Products

Related compounds with same targets

YUKA1 JQKD82 GSK-LSD1 dihydrochloride Kgp-IN-1 LSD1-UM-109 5-Hydroxy-7-acetoxy-8-methoxyflavone LSD1-IN-30 PFI-90

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

LSD1-IN-24 4734-59-2 Apoptosis Cell Cycle/Checkpoint Chromatin/Epigenetic Immunology/Inflammation Histone Demethylase PD-1/PD-L1 LSD1IN24 inhibitor inhibit

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