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LSD1-IN-24

Name: LSD1-IN-24
Brand: TargetMol
SKU: T67871
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T67871Cas No. 4734-59-2

LSD1-IN-24 is a selective and potent LSD1 inhibitor with an IC50 value of 0.247 μM.LSD1-IN-24 induces PD-L1 expression and enhances the T cell killing response, and can be used in cancer-related diseases.

LSD1-IN-24

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Purity: 99.61%

Catalog No. T67871Cas No. 4734-59-2

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$31	-	In Stock
5 mg	$74	-	In Stock
10 mg	$118	-	In Stock
25 mg	$236	-	In Stock
50 mg	$387	-	In Stock
100 mg	$592	-	In Stock
200 mg	$783	-	In Stock
1 mL x 10 mM (in DMSO)	$81	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.61%

Appearance:Solid

Color:Yellow

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	LSD1-IN-24 is a selective and potent LSD1 inhibitor with an IC50 value of 0.247 μM.LSD1-IN-24 induces PD-L1 expression and enhances the T cell killing response, and can be used in cancer-related diseases.
In vitro	LSD1-IN-24 (compound 3S) (0-20 μM, 5 days) can dose-dependently reduce PD-L1 levels in an LSD1-dependent manner and enhance T-cell cytotoxicity against BGC-823 cells. It does not affect the proliferation of BGC-823 and MFC cells. Additionally, it can dose-dependently protect H3K4me1/2 from demethylation but cannot protect H3K4me3[1].
In vivo	In a subcutaneous tumor model containing MFC cells, LSD1-IN-24 (compound 3S) (0-50 mg/kg, oral gavage; daily for 2 weeks) dose-dependently inhibits the in vivo growth of MFC cells. The tumor weight significantly decreases, Ki67 expression in tumor tissues markedly decreases, and there is no apparent toxicity observed in mice[1].

Chemical Properties

Molecular Weight	312.43
Formula	C₁₈H₂₀N₂OS
Cas No.	4734-59-2
Smiles	O1CCN(CC1)CCN2C=3C=CC=CC3SC=4C=CC=CC42
Relative Density.	no data available

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (160.04 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.4 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2007 mL	16.0036 mL	32.0072 mL	160.0358 mL
5 mM	0.6401 mL	3.2007 mL	6.4014 mL	32.0072 mL
10 mM	0.3201 mL	1.6004 mL	3.2007 mL	16.0036 mL
20 mM	0.1600 mL	0.8002 mL	1.6004 mL	8.0018 mL
50 mM	0.0640 mL	0.3201 mL	0.6401 mL	3.2007 mL
100 mM	0.0320 mL	0.1600 mL	0.3201 mL	1.6004 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc