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LSD1-IN-24

Name: LSD1-IN-24
Brand: TargetMol
SKU: T67871
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T67871Cas No. 4734-59-2

LSD1-IN-24 is a selective and potent LSD1 inhibitor with an IC50 value of 0.247 μM.LSD1-IN-24 induces PD-L1 expression and enhances the T cell killing response, and can be used in cancer-related diseases.

LSD1-IN-24

🥰Excellent

Purity: 99.53%

Catalog No. T67871Cas No. 4734-59-2

Pack Size	Price	Availability
1 mg	$31	In Stock
5 mg	$74	In Stock
10 mg	$118	In Stock
25 mg	$236	In Stock
50 mg	$387	In Stock
100 mg	$592	In Stock
200 mg	$783	In Stock
1 mL x 10 mM (in DMSO)	$81	In Stock

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Batch Information

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Purity:99.53%

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Product Introduction

Bioactivity

Description	LSD1-IN-24 is a selective and potent LSD1 inhibitor with an IC50 value of 0.247 μM.LSD1-IN-24 induces PD-L1 expression and enhances the T cell killing response, and can be used in cancer-related diseases.
In vitro	LSD1-IN-24 (compound 3S) (0-20 μM, 5 days) can dose-dependently reduce PD-L1 levels in an LSD1-dependent manner and enhance T-cell cytotoxicity against BGC-823 cells. It does not affect the proliferation of BGC-823 and MFC cells. Additionally, it can dose-dependently protect H3K4me1/2 from demethylation but cannot protect H3K4me3[1].
In vivo	In a subcutaneous tumor model containing MFC cells, LSD1-IN-24 (compound 3S) (0-50 mg/kg, oral gavage; daily for 2 weeks) dose-dependently inhibits the in vivo growth of MFC cells. The tumor weight significantly decreases, Ki67 expression in tumor tissues markedly decreases, and there is no apparent toxicity observed in mice[1].

Chemical Properties

Molecular Weight	312.43
Formula	C₁₈H₂₀N₂OS
Cas No.	4734-59-2
Smiles	O1CCN(CC1)CCN2C=3C=CC=CC3SC=4C=CC=CC42
Relative Density.	no data available
Color	Yellow
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (160.04 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2007 mL	16.0036 mL	32.0072 mL	160.0358 mL
5 mM	0.6401 mL	3.2007 mL	6.4014 mL	32.0072 mL
10 mM	0.3201 mL	1.6004 mL	3.2007 mL	16.0036 mL
20 mM	0.1600 mL	0.8002 mL	1.6004 mL	8.0018 mL
50 mM	0.0640 mL	0.3201 mL	0.6401 mL	3.2007 mL
100 mM	0.0320 mL	0.1600 mL	0.3201 mL	1.6004 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc