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TGF beta 1 Protein, Human, Recombinant (Avi), Biotinylated

Catalog No. TMPJ-00249
Synonyms: TGF-Beta-1, TGFB1, Transforming Growth Factor β-1, Latency-Associated Peptide, TGF-β-1, Transforming Growth Factor Beta-1, TGFB, LAP, TGF-β1

Transforming Growth Factor β-1 (TGFβ-1) is a secreted protein which belongs to the TGF-β family. TGFβ-1 is abundantly expressed in bone, articular cartilage and chondrocytes and is increased in osteoarthritis (OA). TGFβ-1 performs many cellular functions, including the control of cell growth, cell proliferation, cell differentiation and apoptosis. The precursor is cleaved into a latency-associated peptide (LAP) and a mature TGFβ-1 peptide. TGFβ-1 may also form heterodimers with other TGFβ family members. It has been found that TGFβ-1 is frequently upregulated in tumor cells. Mutations in this gene results in Camurati-Engelmann disease.

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TGF beta 1 Protein, Human, Recombinant (Avi), Biotinylated
Pack Size Availability Price/USD Quantity
20 μg In stock $ 579.00
100 μg 5 days $ 1,600.00
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Biological Description
Technical Params
Product Properties
Biological Information 1. Measured by its ability to inhibit TGF-beta 1 activity on TF‑1 human erythroleukemic cells. The ED50 for this effect is 137.37pg/ml. (Regularly tested) 2. Immobilized Biotinylated Human TGF-beta 1-Avi at 2μg/ml (100 μl/well) can bind Human TGFBR2-Fc. The ED50 of Human TGFBR2-Fc is 9.47ng/ml. (Regularly tested)

Description Transforming Growth Factor β-1 (TGFβ-1) is a secreted protein which belongs to the TGF-β family. TGFβ-1 is abundantly expressed in bone, articular cartilage and chondrocytes and is increased in osteoarthritis (OA). TGFβ-1 performs many cellular functions, including the control of cell growth, cell proliferation, cell differentiation and apoptosis. The precursor is cleaved into a latency-associated peptide (LAP) and a mature TGFβ-1 peptide. TGFβ-1 may also form heterodimers with other TGFβ family members. It has been found that TGFβ-1 is frequently upregulated in tumor cells. Mutations in this gene results in Camurati-Engelmann disease.
Species Human
Expression System Human Cells
Tag N-Avi
Accession Number P01137
Synonyms TGF-Beta-1, TGFB1, Transforming Growth Factor β-1, Latency-Associated Peptide, TGF-β-1, Transforming Growth Factor Beta-1, TGFB, LAP, TGF-β1
Amino Acid Ala279-Ser390
Construction Biotinylated Recombinant Human Transforming Growth Factor beta 1 is produced by our Mammalian expression system and the target gene encoding Ala279-Ser390 is expressed with a Avi tag at the N-terminus.
Protein Purity Greater than 95% as determined by reducing SDS-PAGE. (QC verified)

Molecular Weight 12-18 KDa, reducing conditions
Endotoxin Less than 10EU/mg as determined by LAL test.
Formulation Lyophilized from a 0.2 μm filtered solution of 50mM Glycine-HCl, 150mM NaCl, pH2.5.
Reconstitution Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. 
Stability & Storage

Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.

Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature listed below.

Research Background Transforming Growth Factor β-1 (TGFβ-1) is a secreted protein which belongs to the TGF-β family. TGFβ-1 is abundantly expressed in bone, articular cartilage and chondrocytes and is increased in osteoarthritis (OA). TGFβ-1 performs many cellular functions, including the control of cell growth, cell proliferation, cell differentiation and apoptosis. The precursor is cleaved into a latency-associated peptide (LAP) and a mature TGFβ-1 peptide. TGFβ-1 may also form heterodimers with other TGFβ family members. It has been found that TGFβ-1 is frequently upregulated in tumor cells. Mutations in this gene results in Camurati-Engelmann disease.

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Keywords

TGF beta 1 Protein, Human, Recombinant (Avi), Biotinylated TGF-Beta-1 TGFB-1 TGFB1 Transforming Growth Factor β-1 TGF-b-1 Latency-Associated Peptide TGF-β-1 TGFB 1 Transforming Growth Factor Beta-1 TGFB Transforming Growth Factor b-1 LAP TGF-β1 recombinant recombinant-proteins proteins protein

 

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