SYK-1106 dihydrochloride

Name: SYK-1106 dihydrochloride
Brand: TargetMol
SKU: T214696
Rating: 4.5 (1 reviews)

Catalog No. T214696 Copy Product Info

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SYK-1106 dihydrochloride is a selective δ-opioid receptor (DOR) agonist with an EC50 of 0.089 nM. It exhibits high selectivity for DOR over MOR and KOR. In the forced swim test in mice, SYK-1106 dihydrochloride demonstrated antidepressant-like effects and is utilized in depression research.

SYK-1106 dihydrochloride

Copy Product Info

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Catalog No. T214696

SYK-1106 dihydrochloride

Pack Size	Price	USA Stock	Global Stock	Quantity
10 mg	Inquiry	Inquiry	Inquiry
50 mg	Inquiry	Inquiry	Inquiry

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Product Introduction

Bioactivity

Description	SYK-1106 dihydrochloride is a selective δ-opioid receptor (DOR) agonist with an EC50 of 0.089 nM. It exhibits high selectivity for DOR over MOR and KOR. In the forced swim test in mice, SYK-1106 dihydrochloride demonstrated antidepressant-like effects and is utilized in depression research.
Targets&IC50	δ opioid receptor:0.089 nM (EC50)
In vitro	SYK-1106 dihydrochloride exhibits the highest efficacy (Emax = 111%) and potency (EC50 = 0.089 nM) towards the δ-opioid receptor (DOR), with minimal agonist activity on the μ-opioid receptor (MOR) and κ-opioid receptor (KOR). It binds to DOR, KOR, and MOR with Ki values of 0.848 nM, 2.45 nM, and 9.54 nM, respectively.
In vivo	SYK-1106 (0.3 mg/kg, subcutaneous injection) dihydrochloride exhibits potent, dose-dependent antidepressant-like effects in the forced swim test in mice, without causing convulsions.

Chemical Properties

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

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You can also refer to dose conversion for different animals. More Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc