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AKR1C4 Protein, Human, Recombinant (His)

Catalog No. TMPY-00481
Synonyms: aldo-keto reductase family 1, member C4, 3-alpha-HSD, DD4, CHDR, AKR1C4, HAKRA, CDR, C11, DD-4, 3-α-HSD

Aldo-keto reductases comprise of AKR1C1-AKR1C4, four enzymes that catalyze NADPH dependent reductions and have been implicated in biosynthesis, intermediary metabolism, and detoxification. there is a strong correlation between the expression levels of these family members and the malignant transformation as well as the resistance to cancer therapy. Type I human hepatic 3alpha-hydroxysteroid dehydrogenase (AKR1C4) plays a significant role in bile acid biosynthesis, steroid hormone metabolism, and xenobiotic metabolism.

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AKR1C4 Protein, Human, Recombinant (His)
Pack Size Availability Price/USD Quantity
50 μg 5 days $ 600.00
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Biological Description
Technical Params
Product Properties
Description Aldo-keto reductases comprise of AKR1C1-AKR1C4, four enzymes that catalyze NADPH dependent reductions and have been implicated in biosynthesis, intermediary metabolism, and detoxification. there is a strong correlation between the expression levels of these family members and the malignant transformation as well as the resistance to cancer therapy. Type I human hepatic 3alpha-hydroxysteroid dehydrogenase (AKR1C4) plays a significant role in bile acid biosynthesis, steroid hormone metabolism, and xenobiotic metabolism.
Species Human
Expression System E. coli
Tag His
Accession Number AAH20744.1
Synonyms aldo-keto reductase family 1, member C4, 3-alpha-HSD, DD4, CHDR, AKR1C4, HAKRA, CDR, C11, DD-4, 3-α-HSD
Construction A DNA sequence encoding the human AKR1C4 (AAH20744.1) (Met1-Tyr323) was expressed with a polyhistidine tag at the N-terminus.
Protein Purity > 85 % as determined by SDS-PAGE
Molecular Weight Approxiamtely 39.4 kDa
Endotoxin Please contact us for more information.
Formulation Lyophilized from sterile PBS, pH 7.4. Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0. 01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
Reconstitution A hardcopy of datasheet with reconstitution instructions is sent along with the products. Please refer to it for detailed information.
Stability & Storage

Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

Shipping

In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.

Research Background Aldo-keto reductases comprise of AKR1C1-AKR1C4, four enzymes that catalyze NADPH dependent reductions and have been implicated in biosynthesis, intermediary metabolism, and detoxification. there is a strong correlation between the expression levels of these family members and the malignant transformation as well as the resistance to cancer therapy. Type I human hepatic 3alpha-hydroxysteroid dehydrogenase (AKR1C4) plays a significant role in bile acid biosynthesis, steroid hormone metabolism, and xenobiotic metabolism.

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Keywords

AKR1C4 Protein, Human, Recombinant (His) aldo-keto reductase family 1, member C4 3-a-HSD C-11 3-alpha-HSD DD4 CHDR AKR1C4 HAKRA CDR C 11 C11 DD 4 DD-4 3-α-HSD recombinant recombinant-proteins proteins protein

 

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