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Anti-TBC1D4 Monoclonal Antibody (5N109)
(Synonyms: NIDDM5, AS160) Copy Product Info
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Synonyms: NIDDM5, AS160
Catalog No. TMAT-0594 Copy Product Info
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Anti-TBC1D4 Monoclonal Antibody (5N109) is a Mouse antibody targeting TBC1D4. Anti-TBC1D4 Monoclonal Antibody (5N109) can be used in FCM.
Anti-TBC1D4 Monoclonal Antibody
(5N109)
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 20 µL | Inquiry | 7-10 days | 7-10 days | |
| 50 µL | Inquiry | 7-10 days | 7-10 days | |
| 100 µL | Inquiry | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Related Conjugates and Formulations
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Stability & Storage
| Description | Anti-TBC1D4 Monoclonal Antibody (5N109) is a Mouse antibody targeting TBC1D4. Anti-TBC1D4 Monoclonal Antibody (5N109) can be used in FCM. |
| Synonyms | NIDDM5, AS160 |
| Ig Type | IgG1 |
| Clone | 5N109 |
| Reactivity | Human |
| Application | |
| Recommended Dose | FCM: 1/200-1/400 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | Hybridoma Monoclonal Antibody |
| Purification | Purified by protein A or protein G |
| Appearance | Liquid |
| Formulation | PBS with 0.05% sodium azide |
| Concentration | 1 mg/ml |
| Research Background | This gene is a member of the Tre-2/BUB2/CDC16 domain family. The protein encoded by this gene is a Rab-GTPase-activating protein, and contains two phopshotyrosine-binding domains (PTB1 and PTB2), a calmodulin-binding domain (CBD), a Rab-GTPase domain, and multiple AKT phosphomotifs. This protein is thought to play an important role in glucose homeostasis by regulating the insulin-dependent trafficking of the glucose transporter 4 (GLUT4), important for removing glucose from the bloodstream into skeletal muscle and fat tissues. Reduced expression of this gene results in an increase in GLUT4 levels at the plasma membrane, suggesting that this protein is important in intracellular retention of GLUT4 under basal conditions. When exposed to insulin, this protein is phosphorylated, dissociates from GLUT4 vesicles, resulting in increased GLUT4 at the cell surface, and enhanced glucose transport. Phosphorylation of this protein by AKT is required for proper translocation of GLUT4 to the cell surface. Individuals homozygous for a mutation in this gene are at higher risk for type 2 diabetes and have higher levels of circulating glucose and insulin levels after glucose ingestion. Alternative splicing results in multiple transcript variants encoding different isoforms. |
| Conjucates | Unconjugated |
| Immunogen | Purified recombinant fragment of human TBC1D4 (AA: 574-712) expressed in E. Coli. |
| Antigen Species | Human |
| Gene Name | TBC1D4 |
| Gene ID | |
| Protein Name | TBC1 domain family member 4 |
| Uniprot ID |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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