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SB 216641 hydrochloride

Name: SB 216641 hydrochloride
Brand: TargetMol
SKU: T23315
Price: 40 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: SB-216641A, SB216641A, SB-216641 hydrochloride, SB 216641A) Copy Product Info

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Synonyms: SB-216641A, SB216641A, SB-216641 hydrochloride, SB 216641A

Catalog No. T23315 Copy Product Info

Purity: 99.23%

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SB 216641 hydrochloride (SB-216641A) is a selective 5-HT₁B/D receptor antagonist with binding affinities (K_i) of 0.9 nM and 1.8 nM for human and rat 5-HT₁B receptors, respectively. SB 216641 hydrochloride is primarily used in studies of 5-HT₁B-mediated neuroregulation, migraine, anxiety, and vascular responses.

Cas No. 193611-67-5

Pack Size	Price	USA Stock	Global Stock
1 mg	$40	In Stock	In Stock
5 mg	$92	In Stock	In Stock
10 mg	$133	In Stock	In Stock
25 mg	$225	In Stock	In Stock
50 mg	$333	In Stock	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Batch Information

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Purity:99.23%

Appearance:Solid

Color:Yellow to Brown

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	SB 216641 hydrochloride (SB-216641A) is a selective 5-HT₁B/D receptor antagonist with binding affinities (K_i) of 0.9 nM and 1.8 nM for human and rat 5-HT₁B receptors, respectively. SB 216641 hydrochloride is primarily used in studies of 5-HT₁B-mediated neuroregulation, migraine, anxiety, and vascular responses.
Targets & IC50	5-HT1B (CHO cell):9.0 (pKi), 5-HT1B (Endothelial cells):1.5 μM
In vivo	Methods: Newborn Wistar rats received two subcutaneous injections of DSP-4 (50 mg/kg) on days 1 and 3 postnatal. At adulthood (10 weeks), neostigmine (4.0 mg/kg) administered 30 minutes prior to CP 94,253 (4.0 mg/kg) reduced norepinephrine levels in the medial prefrontal cortex by approximately 95%, confirming successful lesion formation. Adult control and DSP-4 groups received CP 94,253 (4.0 mg/kg) and SB 216641 hydrochloride (4.0 mg/kg) administered 30 minutes prior to the agonist. Results: In the control group, CP 94,253 induced an anxiety-like effect (significant increase in time spent in the closed arm), which was blocked by SB 216641 hydrochloride. [1] Methods: Four female Beagle dogs (12–16 kg) underwent surgical gastric intubation. SB 216641 hydrochloride (559 nmol/kg) was administered intravenously 30 minutes before the fourth round of dilation. Sumatriptan was administered intravenously 15 minutes before the fourth round of dilation. Results: Sumatriptan promotes gastric receptivity via 5-HT1B receptors. [2]
Synonyms	SB-216641A, SB216641A, SB-216641 hydrochloride, SB 216641A

Chemical Properties

Molecular Weight	523.02
Formula	C₂₈H₃₁ClN₄O₄
Cas No.	193611-67-5
Smiles	Cl.O=C(NC1=CC=C(OC)C(OCCN(C)C)=C1)C=2C=CC(=CC2)C=3C=CC(=CC3C)C4=NOC(=N4)C
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 72.14 mg/mL (137.93 mM)

H2O: 20 mg/mL (38.24 mM), Sonication is recommended.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9120 mL	9.5599 mL	19.1197 mL	95.5986 mL
5 mM	0.3824 mL	1.9120 mL	3.8239 mL	19.1197 mL
10 mM	0.1912 mL	0.9560 mL	1.9120 mL	9.5599 mL
20 mM	0.0956 mL	0.4780 mL	0.9560 mL	4.7799 mL

DMSO

	1mg	5mg	10mg	50mg
50 mM	0.0382 mL	0.1912 mL	0.3824 mL	1.9120 mL
100 mM	0.0191 mL	0.0956 mL	0.1912 mL	0.9560 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Keywords

SB216641 Hydrochloride5HTReceptor5-HT1D5-HT1B5HT Receptor

Related Tags: SB 216641 hydrochloride chemical structure | SB 216641 hydrochloride in vivo | SB 216641 hydrochloride formula | SB 216641 hydrochloride molecular weight