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SB 216641 hydrochloride

🥰Excellent
Catalog No. T23315Cas No. 193611-67-5
Alias SB-216641A, SB216641A, SB-216641 hydrochloride, SB 216641A

SB 216641 hydrochloride (SB-216641A) is a selective 5-HT1B/D receptor antagonist with anxiolytic properties that antagonizes the vasoconstrictor response mediated by sumatriptan. 10-O-Methylprotosapphosporin is an HbF inducer that can be used in the study of metabolic disorders and diabetes.

SB 216641 hydrochloride
Other Forms of SB 216641 hydrochloride:
SB 216641T85323170230-39-4
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SB 216641 hydrochloride

🥰Excellent
Purity: 99.23%
Catalog No. T23315Alias SB-216641A, SB216641A, SB-216641 hydrochloride, SB 216641ACas No. 193611-67-5
SB 216641 hydrochloride (SB-216641A) is a selective 5-HT1B/D receptor antagonist with anxiolytic properties that antagonizes the vasoconstrictor response mediated by sumatriptan. 10-O-Methylprotosapphosporin is an HbF inducer that can be used in the study of metabolic disorders and diabetes.
Pack SizePriceAvailabilityQuantity
1 mg$40In Stock
5 mg$92In Stock
10 mg$133In Stock
25 mg$225In Stock
50 mg$333In Stock
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This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
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Purity:99.23%
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COA HNMR LCMS

Product Introduction

Bioactivity
Description
SB 216641 hydrochloride (SB-216641A) is a selective 5-HT1B/D receptor antagonist with anxiolytic properties that antagonizes the vasoconstrictor response mediated by sumatriptan. 10-O-Methylprotosapphosporin is an HbF inducer that can be used in the study of metabolic disorders and diabetes.
Targets&IC50
5-HT1B (CHO cell):9.0 (pKi), 5-HT1B (Endothelial cells):1.5 μM
In vivo
In guinea pigs, SB 216641 hydrochloride (0.6, 2.0, 6.0, and 20.0 mg/kg; intraperitoneal injection; single dose) significantly blocked the effects of SKF-99101H[1].
SynonymsSB-216641A, SB216641A, SB-216641 hydrochloride, SB 216641A
Chemical Properties
Molecular Weight523.02
FormulaC28H31ClN4O4
Cas No.193611-67-5
SmilesCl.O=C(NC1=CC=C(OC)C(OCCN(C)C)=C1)C=2C=CC(=CC2)C=3C=CC(=CC3C)C4=NOC(=N4)C
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 72.14 mg/mL (137.93 mM)
H2O: 20 mg/mL (38.2 mM), Sonication is recommended.
Solution Preparation Table
H2O/DMSO
1mg5mg10mg50mg
1 mM1.9120 mL9.5599 mL19.1197 mL95.5986 mL
5 mM0.3824 mL1.9120 mL3.8239 mL19.1197 mL
10 mM0.1912 mL0.9560 mL1.9120 mL9.5599 mL
20 mM0.0956 mL0.4780 mL0.9560 mL4.7799 mL
DMSO
1mg5mg10mg50mg
50 mM0.0382 mL0.1912 mL0.3824 mL1.9120 mL
100 mM0.0191 mL0.0956 mL0.1912 mL0.9560 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
% DMSO
%
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Keywords

SB216641 Hydrochloride5HTReceptor5-HT1D5-HT1B5HT Receptor
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