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SB 216641 hydrochloride

Name: SB 216641 hydrochloride
Brand: TargetMol
SKU: T23315
Price: 40 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T23315Cas No. 193611-67-5

Alias SB-216641A, SB216641A, SB-216641 hydrochloride, SB 216641A

SB 216641 hydrochloride (SB-216641A) is a selective 5-HT1B/D receptor antagonist with anxiolytic properties that antagonizes the vasoconstrictor response mediated by sumatriptan. 10-O-Methylprotosapphosporin is an HbF inducer that can be used in the study of metabolic disorders and diabetes.

SB 216641 hydrochloride

🥰Excellent

Purity: 99.23%

Catalog No. T23315Alias SB-216641A, SB216641A, SB-216641 hydrochloride, SB 216641ACas No. 193611-67-5

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$40	In Stock	In Stock
5 mg	$92	In Stock	In Stock
10 mg	$133	In Stock	In Stock
25 mg	$225	In Stock	In Stock
50 mg	$333	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:99.23%

Appearance:Solid

Color:Yellow to Brown

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	SB 216641 hydrochloride (SB-216641A) is a selective 5-HT1B/D receptor antagonist with anxiolytic properties that antagonizes the vasoconstrictor response mediated by sumatriptan. 10-O-Methylprotosapphosporin is an HbF inducer that can be used in the study of metabolic disorders and diabetes.
Targets&IC50	5-HT1B (CHO cell):9.0 (pKi), 5-HT1B (Endothelial cells):1.5 μM
In vivo	In guinea pigs, SB 216641 hydrochloride (0.6, 2.0, 6.0, and 20.0 mg/kg; intraperitoneal injection; single dose) significantly blocked the effects of SKF-99101H[1].
Synonyms	SB-216641A, SB216641A, SB-216641 hydrochloride, SB 216641A

Chemical Properties

Molecular Weight	523.02
Formula	C₂₈H₃₁ClN₄O₄
Cas No.	193611-67-5
Smiles	Cl.O=C(NC1=CC=C(OC)C(OCCN(C)C)=C1)C=2C=CC(=CC2)C=3C=CC(=CC3C)C4=NOC(=N4)C
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 72.14 mg/mL (137.93 mM)

H2O: 20 mg/mL (38.24 mM), Sonication is recommended.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9120 mL	9.5599 mL	19.1197 mL	95.5986 mL
5 mM	0.3824 mL	1.9120 mL	3.8239 mL	19.1197 mL
10 mM	0.1912 mL	0.9560 mL	1.9120 mL	9.5599 mL
20 mM	0.0956 mL	0.4780 mL	0.9560 mL	4.7799 mL

DMSO

	1mg	5mg	10mg	50mg
50 mM	0.0382 mL	0.1912 mL	0.3824 mL	1.9120 mL
100 mM	0.0191 mL	0.0956 mL	0.1912 mL	0.9560 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc