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CNS-5161 hydrochloride

Name: CNS-5161 hydrochloride
Brand: TargetMol
SKU: T10852
Price: 509 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: CNS 5161A) Copy Product Info

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Synonyms: CNS 5161A

Catalog No. T10852 Copy Product Info

Purity: 99.53%

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CNS-5161 hydrochloride (CNS 5161A) is a small molecule antagonist and an NMDA receptor antagonist that selectively and non-competitively blocks the action of glutamate, and can be used for research on neurological diseases.

Cas No. 160756-38-7

Pack Size	Price	USA Stock	Global Stock
1 mg	$509	In Stock	In Stock
5 mg	$1,000	In Stock	In Stock
10 mg	$1,360	In Stock	In Stock
25 mg	$2,020	In Stock	In Stock
50 mg	$2,710	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$1,150	In Stock	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.53%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	CNS-5161 hydrochloride (CNS 5161A) is a small molecule antagonist and an NMDA receptor antagonist that selectively and non-competitively blocks the action of glutamate, and can be used for research on neurological diseases.
Targets & IC50	NMDA:1.8 nM (Ki)
In vitro	Methods: Rat brain synaptosomal membrane preparations were used to determine the inhibitory activity of CNS-5161 hydrochloride by radioligand competition binding assays. Results: CNS-5161 hydrochloride displaced [3H] MK-801 binding with a Ki value of 1.8 nM, showing potent inhibition of the NMDA ion channel.[1]
In vivo	Methods: To evaluate the in vivo activity of CNS-5161 hydrochloride, 4 mg/kg CNS-5161 hydrochloride was administered by intraperitoneal injection in the neonatal rat NMDA excitotoxicity model; 4 mg/kg was administered by intraperitoneal injection in the DBA/2 mouse audiogenic seizure model; and intraperitoneal injection was administered in the neonatal rat hypoxic/ischemic brain injury model. Results: CNS-5161 hydrochloride effectively counteracted the necrotic effects of NMDA at a dose of 4 mg/kg, achieved 91% inhibition of audiogenic seizures, and showed neuroprotective effects against hypoxic/ischemic brain injury. [1]
Synonyms	CNS 5161A

Chemical Properties

Molecular Weight	388.38
Formula	C₁₆H₁₉Cl₂N₃S₂
Cas No.	160756-38-7
Smiles	Cl.ClC1=CC=C(SC)C=C1NC(=N)N(C=2C=CC=C(SC)C2)C
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 245 mg/mL (630.83 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5748 mL	12.8740 mL	25.7480 mL	128.7399 mL
5 mM	0.5150 mL	2.5748 mL	5.1496 mL	25.7480 mL
10 mM	0.2575 mL	1.2874 mL	2.5748 mL	12.8740 mL
20 mM	0.1287 mL	0.6437 mL	1.2874 mL	6.4370 mL
50 mM	0.0515 mL	0.2575 mL	0.5150 mL	2.5748 mL
100 mM	0.0257 mL	0.1287 mL	0.2575 mL	1.2874 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

NMDA receptor/ion channelNMDACNS-5161 HydrochlorideCNS5161 HydrochlorideCNS 5161 Hydrochloride

Related Tags: CNS-5161 hydrochloride chemical structure | CNS-5161 hydrochloride in vivo | CNS-5161 hydrochloride in vitro | CNS-5161 hydrochloride formula | CNS-5161 hydrochloride molecular weight