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FGIN-1-27

Name: FGIN-1-27
Brand: TargetMol
SKU: T22782
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T22782Cas No. 142720-24-9

FGIN-1-27 is a high-affinity agonist of the translocator protein and a specific peripheral benzodiazepine receptor (PBR) ligand(Ki = 5.0 nM). FGIN 1-27 can cross the blood-brain barrier.

FGIN-1-27

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Purity: 99.86%

Catalog No. T22782Cas No. 142720-24-9

FGIN-1-27 is a high-affinity agonist of the translocator protein and a specific peripheral benzodiazepine receptor (PBR) ligand(Ki = 5.0 nM). FGIN 1-27 can cross the blood-brain barrier.

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$38	In Stock	In Stock
25 mg	$77	In Stock	In Stock
50 mg	$118	In Stock	In Stock
100 mg	$197	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$30	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.86%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

FGIN-1-27 AI Summary

FGIN-1-27 exhibits a wide range of bioactivities across multiple targets and cell types. It demonstrates high binding affinity to the mitochondrial DBI receptor complex (TSPO) in glial cells with a Ki value of 4.4 nM and displaces [3H]PK11195 binding from the peripheral benzodiazepine receptor in C6 rat glioma and MA-10 mouse Leydig cells, with an IC50 of 10.0 nM. Additionally, it binds to human PBR with a Kd of 4.0 nM and shows antineophobic and anti-anxiety activities in rats, indicated by increased entries and time spent in the open arms of an elevated maze test. It enhances pregnenolone formation in the mitochondria of C6-2B glioma cells with an EC50 of 3.0 nM. Additionally, FGIN-1-27 demonstrates antiplasmodial activity against Plasmodium falciparum with IC50 values ranging from 3162.28 nM to 10000.0 nM. The compound also exhibits antiviral properties, inhibiting SARS-CoV-2 induced cytotoxicity in Caco-2 cells by 73.55% at 10 µM after 48 hours and showing limited inhibition against SARS-CoV-2 3CL-Pro protease and cytotoxicity in VERO-6 cells. It has shown potential HDAC6 inhibitory activity, although this finding requires further investigation. Overall, FGIN-1-27 displays a diverse array of bioactivities across neuroprotective, antimalarial, and antiviral properties..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	FGIN-1-27 is a high-affinity agonist of the translocator protein and a specific peripheral benzodiazepine receptor (PBR) ligand(Ki = 5.0 nM). FGIN 1-27 can cross the blood-brain barrier.
Targets&IC50	PBR:5.0 nM(Ki)

Chemical Properties

Molecular Weight	436.6
Formula	C₂₈H₃₇FN₂O
Cas No.	142720-24-9
Smiles	CCCCCCN(CCCCCC)C(=O)Cc1c([nH]c2ccccc12)-c1ccc(F)cc1
Relative Density.	1.0538 g/cm3 (Estimated)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 4.37 mg/mL (10.01 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (2.29 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2904 mL	11.4521 mL	22.9043 mL	114.5213 mL
5 mM	0.4581 mL	2.2904 mL	4.5809 mL	22.9043 mL
10 mM	0.2290 mL	1.1452 mL	2.2904 mL	11.4521 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc