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D-Alanine
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Catalog No. T4811Cas No. 338-69-2
Alias D-α-Alanine, Ba 2776, (R)-Alanine, (R)-2-Aminopropionic acid
Alanine is a nonessential amino acid made in the body from the conversion of the carbohydrate pyruvate or the breakdown of DNA and the dipeptides carnosine and anserine. D-Alanine ((R)-Alanine) is a weak GlyR (inhibitory glycine receptor) and PMBA agonist, with an EC50 of 9 mM for GlyR.
D-Alanine
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Purity: 99.81%
Catalog No. T4811Alias D-α-Alanine, Ba 2776, (R)-Alanine, (R)-2-Aminopropionic acidCas No. 338-69-2
Alanine is a nonessential amino acid made in the body from the conversion of the carbohydrate pyruvate or the breakdown of DNA and the dipeptides carnosine and anserine. D-Alanine ((R)-Alanine) is a weak GlyR (inhibitory glycine receptor) and PMBA agonist, with an EC50 of 9 mM for GlyR.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 500 mg | $29 | Inquiry | Inquiry | |
| 1 mL x 10 mM (in DMSO) | $29 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.81%
Appearance:Solid
Color:White
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Product Introduction
D-Alanine AI Summary
D-Alanine exhibits a range of bioactivities targeting various receptors and enzymatic pathways. Primarily, it shows bioactivity in inhibiting the binding of [3H]strychnine to the N-methyl-D-aspartate (NMDA) glutamate receptor 1 in rats, with IC50 values reported at 17000.0 nM and 90900.0 nM. It demonstrates potential as an antagonist for NMDA glutamate receptors by displacing [3H]glycine from the glycine recognition site of these receptors in rat brain cortex membrane, presenting a Ki value of 630.96 nM. Additionally, it interacts with glycine receptors, displacing [3H]glycine with a Ki value of 895.0 nM and achieving an activity of 90.0% in displacing [3H]glycine.
Moreover, D-Alanine shows inhibition of Bacillus subtilis Sfp phosphopantetheinyl transferase, with a range of potency values between 16,944.1 nM and 31,622.78 nM, and inhibits Bacillus anthracis Sterne 34F2 spore germination induced by inosine/L-alanine with an IC50 value of 20000.0 nM. It also exhibits antibacterial activity against Bacillus anthracis Sterne 34F2 in mouse J774A.1 cells, protecting against bacteria-induced cytotoxicity with an IC50 value of 20000.0 nM.
Furthermore, D-Alanine inhibits human PAT1-mediated L-proline uptake in human Caco2 cells, with a Ki value of 19000000.0 nM, and shows inhibitory activity on ASCT2 mediated [3H]-D-serine uptake in rat hippocampal astrocytes at 1 mM after 5 minutes with an inhibition of ≥ 25.0%..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Alanine is a nonessential amino acid made in the body from the conversion of the carbohydrate pyruvate or the breakdown of DNA and the dipeptides carnosine and anserine. D-Alanine ((R)-Alanine) is a weak GlyR (inhibitory glycine receptor) and PMBA agonist, with an EC50 of 9 mM for GlyR. |
| Targets&IC50 | GlyR:9 mM (EC50) |
| Synonyms | D-α-Alanine, Ba 2776, (R)-Alanine, (R)-2-Aminopropionic acid |
| Molecular Weight | 89.09 |
| Formula | C3H7NO2 |
| Cas No. | 338-69-2 |
| Smiles | C[C@@H](N)C(O)=O |
| Relative Density. | 1.161g/cm3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO: Slightly soluble  |
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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