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SJFα

Name: SJFα
Brand: TargetMol
SKU: T18681
Price: 88 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T18681Cas No. 2254609-27-1

Alias SJFalpha, SJF α, SJF alpha

SJFα (SJF alpha) is a PROTAC formed by an E3 ubiquitin ligase-conjugated protein hydrolysis regulator that degrades p38α and p38δ and can be used in cancer research.

SJFα

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Purity: 95.25%

Catalog No. T18681Alias SJFalpha, SJF α, SJF alphaCas No. 2254609-27-1

SJFα (SJF alpha) is a PROTAC formed by an E3 ubiquitin ligase-conjugated protein hydrolysis regulator that degrades p38α and p38δ and can be used in cancer research.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$88	-	In Stock
5 mg	$213	-	In Stock
10 mg	$396	-	In Stock
25 mg	$845	-	In Stock
50 mg	$1,490	-	In Stock
1 mL x 10 mM (in DMSO)	$498	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:95.25%

Appearance:Solid

Color:Yellow

Resource Download

COA HPLC MS HNMR

Product Introduction

Bioactivity

Description	SJFα (SJF alpha) is a PROTAC formed by an E3 ubiquitin ligase-conjugated protein hydrolysis regulator that degrades p38α and p38δ and can be used in cancer research.
Targets&IC50	p38δ:299 nM (DC50), p38δ: 18% (Dmax), p38α:97.4% (Dmax), p38α:7.16 nM (DC50)
In vitro	SJFα PROTAC (13-atom linker, amide attachment) selectively degrades p38α in MDA-MB-231 cells. SJFα degrades p38α with a DC50 = 7.16 nM and Dmax = 97.4%, but is far less effective at degrading p38δ (DC50 = 299 nM, Dmax = 18%) and does not degrade the other p38 isoforms (β and γ). [1]
Synonyms	SJFalpha, SJF α, SJF alpha

Chemical Properties

Molecular Weight	1120.27
Formula	C₅₉H₆₇F₂N₇O₁₁S
Cas No.	2254609-27-1
Smiles	C(NC1=CC(F)=C(OC=2C3=C(C=C(OCCCCOCCCCOCC(N[C@H](C(=O)N4[C@H](C(NCC5=CC=C(C=C5)C=6SC=NC6C)=O)C[C@@H](O)C4)[C@](C)(C)C)=O)C(OC)=C3)N=CC2)C=C1)(=O)C7(C(NC8=CC=C(F)C=C8)=O)CC7
Relative Density.	1.331 g/cm3 (Predicted)

Storage & Solubility Information

Storage

keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL(71.41 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	0.8926 mL	4.4632 mL	8.9264 mL	44.6321 mL
5 mM	0.1785 mL	0.8926 mL	1.7853 mL	8.9264 mL
10 mM	0.0893 mL	0.4463 mL	0.8926 mL	4.4632 mL
20 mM	0.0446 mL	0.2232 mL	0.4463 mL	2.2316 mL
50 mM	0.0179 mL	0.0893 mL	0.1785 mL	0.8926 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc