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SJFα

Name: SJFα
Brand: TargetMol
SKU: T18681
Price: 88 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T18681Cas No. 2254609-27-1

Alias SJFalpha, SJF α, SJF alpha

SJFα (SJF alpha) is a PROTAC formed by an E3 ubiquitin ligase-conjugated protein hydrolysis regulator that degrades p38α and p38δ and can be used in cancer research.

SJFα

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Purity: 95.25%

Catalog No. T18681Alias SJFalpha, SJF α, SJF alphaCas No. 2254609-27-1

SJFα (SJF alpha) is a PROTAC formed by an E3 ubiquitin ligase-conjugated protein hydrolysis regulator that degrades p38α and p38δ and can be used in cancer research.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$88	-	In Stock
5 mg	$213	-	In Stock
10 mg	$396	-	In Stock
25 mg	$845	-	In Stock
50 mg	$1,490	-	In Stock
1 mL x 10 mM (in DMSO)	$498	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:95.25%

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COA HPLC MS

Product Introduction

Bioactivity

Description	SJFα (SJF alpha) is a PROTAC formed by an E3 ubiquitin ligase-conjugated protein hydrolysis regulator that degrades p38α and p38δ and can be used in cancer research.
Targets&IC50	p38α:97.4% (Dmax), p38α:7.16 nM (DC50), p38δ:299 nM (DC50), p38δ: 18% (Dmax)
In vitro	SJFα PROTAC (13-atom linker, amide attachment) selectively degrades p38α in MDA-MB-231 cells. SJFα degrades p38α with a DC50 = 7.16 nM and Dmax = 97.4%, but is far less effective at degrading p38δ (DC50 = 299 nM, Dmax = 18%) and does not degrade the other p38 isoforms (β and γ). [1]
Synonyms	SJFalpha, SJF α, SJF alpha

Chemical Properties

Molecular Weight	1120.27
Formula	C₅₉H₆₇F₂N₇O₁₁S
Cas No.	2254609-27-1
Smiles	C(NC1=CC(F)=C(OC=2C3=C(C=C(OCCCCOCCCCOCC(N[C@H](C(=O)N4[C@H](C(NCC5=CC=C(C=C5)C=6SC=NC6C)=O)C[C@@H](O)C4)[C@](C)(C)C)=O)C(OC)=C3)N=CC2)C=C1)(=O)C7(C(NC8=CC=C(F)C=C8)=O)CC7
Relative Density.	1.331 g/cm3 (Predicted)

Storage & Solubility Information

Storage

keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL(71.41 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	0.8926 mL	4.4632 mL	8.9264 mL	44.6321 mL
5 mM	0.1785 mL	0.8926 mL	1.7853 mL	8.9264 mL
10 mM	0.0893 mL	0.4463 mL	0.8926 mL	4.4632 mL
20 mM	0.0446 mL	0.2232 mL	0.4463 mL	2.2316 mL
50 mM	0.0179 mL	0.0893 mL	0.1785 mL	0.8926 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc