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Retrorsine

Name: Retrorsine
Brand: TargetMol
SKU: TN2147
Rating: 4.5 (1 reviews)

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Catalog No. TN2147Cas No. 480-54-6

Retrorsine selectively inhibits hepatocyte proliferation and following liver injury evokes small hepatocyte-like progenitor cells. Retrorsine can be used for the research of hepatocellular injury.

Retrorsine

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Purity: 97.73%

Catalog No. TN2147Cas No. 480-54-6

Retrorsine selectively inhibits hepatocyte proliferation and following liver injury evokes small hepatocyte-like progenitor cells. Retrorsine can be used for the research of hepatocellular injury.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mg	$127	7-10 days	7-10 days
5 mg	$268	7-10 days	7-10 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:97.73%

Appearance:Solid

Color:White

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	Retrorsine selectively inhibits hepatocyte proliferation and following liver injury evokes small hepatocyte-like progenitor cells. Retrorsine can be used for the research of hepatocellular injury.
Targets&IC50	OCT1:2.2 μM
In vitro	Retrorsine inhibited the OCT1-mediated 1-methyl-4-phenylpyridinium (MPP(+)) uptake in MDCK-hOCT1 cells with the IC50 of 2.25±0.30μM[1]. Retrorsine (60 μM, 120 μM , 240 μM; 24 h) significantly reduced HSEC-CYP3A4 cell viability and GSH levels and increases the formation of pyrrole-protein adducts[2].
In vivo	In male Wistar rats, Retrorsine (30 mg/kg; i.p.; twice) impaired liver regeneration in the PBL model not only by an S or G2/M phase block but also by a block located before the G1/S transition of the cell cycle[3].

Chemical Properties

Molecular Weight	351.39
Formula	C₁₈H₂₅NO₆
Cas No.	480-54-6
Smiles	[H][C@]12CCN3CC=C(COC(=O)[C@@](O)(CO)[C@H](C)C\C(=C\C)C(=O)O1)[C@]23[H]
Relative Density.	1.328g/cm3

Storage & Solubility Information

Storage

keep away from direct sunlight,keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 95 mg/mL (270.35 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 3.3 mg/mL (9.39 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8458 mL	14.2292 mL	28.4584 mL	142.2920 mL
5 mM	0.5692 mL	2.8458 mL	5.6917 mL	28.4584 mL
10 mM	0.2846 mL	1.4229 mL	2.8458 mL	14.2292 mL
20 mM	0.1423 mL	0.7115 mL	1.4229 mL	7.1146 mL
50 mM	0.0569 mL	0.2846 mL	0.5692 mL	2.8458 mL
100 mM	0.0285 mL	0.1423 mL	0.2846 mL	1.4229 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc