CAMKI Protein, Mouse, Recombinant (GST)

Catalog No. TMPC-00109 Copy Product Info

CAMKI Protein, Mouse, Recombinant (GST) is expressed in E. coli. The accession number is Q91YS8.

CAMKI Protein, Mouse, Recombinant (GST)

Catalog No. TMPC-00109

Copy Product Info

CAMKI Protein, Mouse, Recombinant (GST) is expressed in E. coli. The accession number is Q91YS8.

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10 μg	$1,390	Inquiry	Inquiry

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Biological Activity	The specific activity of CAMK1 was determined to be 169 nmol /min/mg by ADP-Glo kinase assay.
Description	CAMKI Protein, Mouse, Recombinant (GST) is expressed in E. coli. The accession number is Q91YS8.
Species	Mouse
Expression System	E. coli
Tag	N-GST
Accession Number	Q91YS8
Synonyms	CaMKI-alpha,CaM-KI,Camk1,CaM kinase I alpha,CaM kinase I,Calcium/calmodulin-dependent protein kinase type 1
Construction	Recombinant full length mouse CAMK1 was expressed in E. coli cells using an N-terminal GST tag.
Protein Purity	>90% as determined by SDS-PAGE.
Molecular Weight	~169 kDa
Formulation	Supplied as sterile 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol.
Stability & Storage	Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	Enzymes are highly recommended to be shipped at frozen temperature with dry ice. Shipment made at ambient temperature may seriously affect the activity of the ordered products.
Research Background	Calcium/calmodulin-dependent protein kinase or CaM kinases are serine/threonine-specific protein kinases that are primarily regulated by the Calcium/calmodulin complex. These kinases show a memory effect on activation. CaM kinases activity can outlast the intracellular calcium transient that is needed to activate it. Inneurons, this property is important for the induction of synaptic plasticity. Pharmacological inhibition of CaM kinases II blocks the induction of long-term potentiation. Upon activation, CaM kinases II phosphorylates postsynaptic glutamate receptors and changes the electrical properties of the synapse. Calcium/calmodulin-dependent protein kinase type 1D, also known as CaM kinase I delta, CaM kinase ID, CaMKI-like protein kinase, CKLiK and CAMK1D, is a member of theprotein kinase superfamily and CaMK subfamily. It contains oneprotein kinase domain. CAMK1D is broadly expressed. It is highly and mostly expressed in polymorphonuclear leukocytes (neutrophilic and eosinophilic granulocytes) while little or no expression is observed in monocytes and lymphocytes. Engineered overexpression of CAMK1D in non-tumorigenic breast epithelial cells led to increased cell proliferation, and molecular and phenotypic alterations indicative of epithelial-mesenchymal transition (EMT), including loss of cell-cell adhesions and increased cell migration and invasion. CAMK1D is a potential therapeutic target with particular relevance to clinically unfavorable basal-like tumors.