IL-17 Protein, Mouse, Recombinant (His)

Name: IL-17 Protein, Mouse, Recombinant (His)
Brand: TargetMol
SKU: TMPJ-01172
Price: 53 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: Interleukin-17A, IL-17A, IL17A, IL-17, IL17, Cytotoxic T-Lymphocyte-Associated Antigen 8, CTLA-8, CTLA8) Copy Product Info

Synonyms: Interleukin-17A, IL-17A, IL17A, IL-17, IL17, Cytotoxic T-Lymphocyte-Associated Antigen 8, CTLA-8, CTLA8

Catalog No. TMPJ-01172 Copy Product Info

Interleukin-17 is a potent pro-inflammatory cytokine produced by activated memory T cells. There are at least six members of the IL-17 family in humans and in mice. Mature mouse IL-17A shares 61% and 89% amino acid sequence identity with human and rat IL-17A, respectively. As IL-17 shares properties with IL-1 and TNF-alpha, it may induce joint inflammation and bone and cartilage destruction. This cytokine is found in synovial fluids of patients with rheumatoid arthritis, and produced by rheumatoid arthritis synovium. It increases IL-6 production, induces collagen degradation and decreases collagen synthesis by synovium and cartilage and proteoglycan synthesis in cartilage. IL-17 is also able to increase bone destruction and reduce its formation. Blocking of interleukin-17 with specific inhibitors provides a protective inhibition of cartilage and bone degradation.

Pack Size	Price	USA Stock	Global Stock
5 µg	$53	-	In Stock
10 µg	$83	-	In Stock
20 µg	$132	7-10 days	7-10 days
50 µg	$250	-	In Stock
100 µg	$392	7-10 days	7-10 days
200 µg	$646	7-10 days	7-10 days
500 µg	$1,220	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:> 99%

Appearance:Lyophilized powder

Color:White

Resource Download

COA User Guide of Recombinant Proteins

Product Introduction

Bioactivity

Bioactivity	1. Loaded Biotinylated Human IL-17RA -His-Avi on SA Biosensor, can bind Mouse IL-17A-His with an affinity constant of 12.6 nM as determined in BLI assay. (Regularly tested) 2. Measured by its ability to induce IL-6 secretion by NIH‑3T3 mouse embryonic fibroblast cells. The ED50 for this effect is 0.25-1.25 ng/ml. (QC verified)
Description	Interleukin-17 is a potent pro-inflammatory cytokine produced by activated memory T cells. There are at least six members of the IL-17 family in humans and in mice. Mature mouse IL-17A shares 61% and 89% amino acid sequence identity with human and rat IL-17A, respectively. As IL-17 shares properties with IL-1 and TNF-alpha, it may induce joint inflammation and bone and cartilage destruction. This cytokine is found in synovial fluids of patients with rheumatoid arthritis, and produced by rheumatoid arthritis synovium. It increases IL-6 production, induces collagen degradation and decreases collagen synthesis by synovium and cartilage and proteoglycan synthesis in cartilage. IL-17 is also able to increase bone destruction and reduce its formation. Blocking of interleukin-17 with specific inhibitors provides a protective inhibition of cartilage and bone degradation.
Species	Mouse
Expression System	HEK293 Cells
Tag	C-6xHis
Accession Number	Q62386
Amino Acid	Thr22-Ala158
Construction	Thr22-Ala158
Protein Purity	Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
Endotoxin	< 0.001 ng/µg (0.01 EU/µg) as determined by LAL test.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4.
Reconstitution	Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
Synonyms	Interleukin-17A, IL-17A, IL17A, IL-17, IL17, Cytotoxic T-Lymphocyte-Associated Antigen 8, CTLA-8, CTLA8
Research Background	Interleukin-17 is a potent pro-inflammatory cytokine produced by activated memory T cells. There are at least six members of the IL-17 family in humans and in mice. Mature mouse IL-17A shares 61% and 89% amino acid sequence identity with human and rat IL-17A, respectively. As IL-17 shares properties with IL-1 and TNF-alpha, it may induce joint inflammation and bone and cartilage destruction. This cytokine is found in synovial fluids of patients with rheumatoid arthritis, and produced by rheumatoid arthritis synovium. It increases IL-6 production, induces collagen degradation and decreases collagen synthesis by synovium and cartilage and proteoglycan synthesis in cartilage. IL-17 is also able to increase bone destruction and reduce its formation. Blocking of interleukin-17 with specific inhibitors provides a protective inhibition of cartilage and bone degradation.

Chemical Properties

Molecular Weight

17-26 KDa (reducing condition)

Storage & Solubility Information

Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Storage	Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.