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IL-17 Protein, Mouse, Recombinant (His)
(Synonyms: Interleukin-17A, IL-17A, IL17A, IL-17, IL17, Cytotoxic T-Lymphocyte-Associated Antigen 8, CTLA-8, CTLA8) Copy Product InfoSynonyms: Interleukin-17A, IL-17A, IL17A, IL-17, IL17, Cytotoxic T-Lymphocyte-Associated Antigen 8, CTLA-8, CTLA8
Catalog No. TMPJ-01172 Copy Product Info
Interleukin-17 is a potent pro-inflammatory cytokine produced by activated memory T cells. There are at least six members of the IL-17 family in humans and in mice. Mature mouse IL-17A shares 61% and 89% amino acid sequence identity with human and rat IL-17A, respectively. As IL-17 shares properties with IL-1 and TNF-alpha, it may induce joint inflammation and bone and cartilage destruction. This cytokine is found in synovial fluids of patients with rheumatoid arthritis, and produced by rheumatoid arthritis synovium. It increases IL-6 production, induces collagen degradation and decreases collagen synthesis by synovium and cartilage and proteoglycan synthesis in cartilage. IL-17 is also able to increase bone destruction and reduce its formation. Blocking of interleukin-17 with specific inhibitors provides a protective inhibition of cartilage and bone degradation.
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 5 μg | $53 | - | In Stock | |
| 10 μg | $83 | - | In Stock | |
| 20 μg | $132 | 7-10 days | 7-10 days | |
| 50 μg | $250 | - | In Stock | |
| 100 μg | $392 | 7-10 days | 7-10 days | |
| 200 μg | $646 | 7-10 days | 7-10 days | |
| 500 μg | $1,220 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:> 99%
Appearance:Lyophilized powder
Color:White
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Interleukin-17 is a potent pro-inflammatory cytokine produced by activated memory T cells. There are at least six members of the IL-17 family in humans and in mice. Mature mouse IL-17A shares 61% and 89% amino acid sequence identity with human and rat IL-17A, respectively. As IL-17 shares properties with IL-1 and TNF-alpha, it may induce joint inflammation and bone and cartilage destruction. This cytokine is found in synovial fluids of patients with rheumatoid arthritis, and produced by rheumatoid arthritis synovium. It increases IL-6 production, induces collagen degradation and decreases collagen synthesis by synovium and cartilage and proteoglycan synthesis in cartilage. IL-17 is also able to increase bone destruction and reduce its formation. Blocking of interleukin-17 with specific inhibitors provides a protective inhibition of cartilage and bone degradation. |
| Species | Mouse |
| Expression System | HEK293 Cells |
| Tag | C-6xHis |
| Accession Number | Q62386 |
| Amino Acid | Thr22-Ala158 |
| Construction | Thr22-Ala158 |
| Protein Purity | Greater than 95% as determined by reducing SDS-PAGE. (QC verified) https://cdn.targetmol.com/group3/M00/12/EA/CgoaEGZG0yWEGIY3AAAAAOgKFrs961.png |
| Endotoxin | < 0.001 ng/µg (0.01 EU/µg) as determined by LAL test. |
| Formulation | Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. |
| Reconstitution | Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing. |
| Stability & Storage | Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
| Shipping | In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice. |
| Synonyms | Interleukin-17A, IL-17A, IL17A, IL-17, IL17, Cytotoxic T-Lymphocyte-Associated Antigen 8, CTLA-8, CTLA8 |
| Research Background |
| Molecular Weight | 17-26 KDa (reducing condition) |
| Storage | Store at low temperature Lyophilized powder: -20~-80°C for 1 year | Solution: -80°C for 6 months |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: IL-17 Protein, Mouse, Recombinant (His) chemical structure | IL-17 Protein, Mouse, Recombinant (His) molecular weight
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