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Streptavidin is a protein tetramer purified from bacteria with a very high affinity for biotin and is commonly used for the purification or detection of various biomolecules. Streptavidin is immunologically active, inhibiting IL-2 synthesis and CD25 expression in T cells.
Description | Streptavidin is a protein tetramer purified from bacteria with a very high affinity for biotin and is commonly used for the purification or detection of various biomolecules. Streptavidin is immunologically active, inhibiting IL-2 synthesis and CD25 expression in T cells. |
In vitro | Compared to the control group, Streptavidin (2-200 μg/mL) significantly inhibits the proliferation of Lewis T cells towards WF, with an inhibition rate of 76%-83% [1]. In Western blot or ELISA, a concentration of 0.1-1 µg/mL is sufficient. For immunoprecipitation, a concentration of 1-10 µg/mL can be used. |
In vivo | In Lewis rat models, subcutaneous administration of Streptavidin induced a significant immunosuppressive effect, including reduced T cell proliferation responses to third-party antigens[1]. |
Cas No. | 9013-20-1 |
Relative Density. | 1.31g/cm3 |
Storage | keep away from moisture | store at -20°C |
Solubility Information | H2O: 80 mg/mL, Sonication is recommended. |
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