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NTRC 0066-0

Name: NTRC 0066-0
Brand: TargetMol
SKU: T28216
Price: 149 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T28216Cas No. 1817791-73-3

Alias NTRC0066-0, NTRC-0066-0, NTRC-00660, NTRC00660, NTRC 00660

NTRC 0066-0 is an orally available, selective and potent inhibitor of threonine tyrosine kinase (TTK) that inhibits phosphorylation of TTK substrates and induces chromosome missegregation in cell lines and mice for cancer research.

NTRC 0066-0

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Purity: 98.30%

Catalog No. T28216Alias NTRC0066-0, NTRC-0066-0, NTRC-00660, NTRC00660, NTRC 00660Cas No. 1817791-73-3

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
2 mg	$149	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:98.30%

Appearance:Solid

Color:Yellow

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	NTRC 0066-0 is an orally available, selective and potent inhibitor of threonine tyrosine kinase (TTK) that inhibits phosphorylation of TTK substrates and induces chromosome missegregation in cell lines and mice for cancer research.
Targets&IC50	TTK:0.9 nM
In vitro	METHODS: To determine the potential relationship between aneuploidy, CIN, and sensitivity to TTK inhibitors, three cell lines that were relatively sensitive to NTRC 0066-0 and three less sensitive cell lines (colon cancer cell line HCT 116, colorectal adenocarcinoma cell line LoVo, and glioblastoma cell line A-172; cervical cancer cell line DoTc2 4520, osteosarcoma cell line MG-63, and ovarian adenocarcinoma cell line OVCAR-3 were selected in a broad cell panel screen and cell proliferation was measured. RESULTS: Colon cancer cell line HCT 116, colorectal adenocarcinoma cell line LoVo, and glioblastoma cell line A-172 were relatively sensitive to NTRC 0066-0, with IC50 values of 37 nM, 40 nM, and 51 nM, respectively. Cervical cancer cell line DoTc2 4520, osteosarcoma cell line MG-63, and ovarian adenocarcinoma cell line OVCAR-3 were less sensitive, with IC50 values of 117 nM, 135 nM, and 872 nM, respectively. [2]
Synonyms	NTRC0066-0, NTRC-0066-0, NTRC-00660, NTRC00660, NTRC 00660

Chemical Properties

Molecular Weight	565.71
Formula	C₃₃H₃₉N₇O₂
Cas No.	1817791-73-3
Smiles	O=C(NC=1C(=CC=CC1CC)CC)C=2C=CN3C4=NC(=NC=C4CCC23)NC5=CC=C(C=C5OC)N6CCN(C)CC6
Relative Density.	1.27 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 15 mg/mL (26.52 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7677 mL	8.8385 mL	17.6769 mL	88.3845 mL
5 mM	0.3535 mL	1.7677 mL	3.5354 mL	17.6769 mL
10 mM	0.1768 mL	0.8838 mL	1.7677 mL	8.8385 mL
20 mM	0.0884 mL	0.4419 mL	0.8838 mL	4.4192 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc