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SK-216
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Catalog No. T28788Cas No. 654080-03-2
Alias SK216
SK-216, a specific PAI-1 inhibitor, reduces tumor angiogenesis and inhibits VEGF-induced migration and tube formation of human umbilical vein endothelial cells in vitro. This compound also alleviates bleomycin-induced pulmonary fibrosis in mice.
SK-216
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Purity: 98.29%
Catalog No. T28788Alias SK216Cas No. 654080-03-2
SK-216, a specific PAI-1 inhibitor, reduces tumor angiogenesis and inhibits VEGF-induced migration and tube formation of human umbilical vein endothelial cells in vitro. This compound also alleviates bleomycin-induced pulmonary fibrosis in mice.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $30 | - | In Stock | |
| 5 mg | $60 | - | In Stock | |
| 10 mg | $98 | - | In Stock | |
| 25 mg | $193 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:98.29%
Appearance:Solid
Color:Brown
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Product Introduction
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Chemical Properties
Storage & Solubility Information
| Description | SK-216, a specific PAI-1 inhibitor, reduces tumor angiogenesis and inhibits VEGF-induced migration and tube formation of human umbilical vein endothelial cells in vitro. This compound also alleviates bleomycin-induced pulmonary fibrosis in mice. |
| In vitro | Methods: Human osteosarcoma cell line 143B was treated with SK-216 (0-50 μM, hours), and the expression of target proteins was detected by Western blot. Results: SK-216 at concentrations of 25 and 50 μM inhibited PAI-1 expression by 40%, resulting in a significant decrease in the ratio of cell invasion pores to total pores, and was able to inhibit the secretion of MMP-13 in 143B cells. [2] |
| In vivo | Methods: SK-216 (6.6 μg/200 μL, intraperitoneal injection, once every three days) was used to treat a mouse model of spontaneous lung metastasis to examine whether it inhibits the lung metastasis of human osteosarcoma cells. Results: SK-216 inhibited the lung metastasis of human osteosarcoma cells from the primary lesion, but did not inhibit tumor growth. [2] |
| Synonyms | SK216 |
| Molecular Weight | 533.52 |
| Formula | C29H29NNa2O6 |
| Cas No. | 654080-03-2 |
| Smiles | O=C([O-])C(C([O-])=O)CCCCCOC1=CC2=CC=C(C=C2C=C1)C3=NC4=CC(C(C)(C)C)=CC=C4O3.[Na+].[Na+] |
| Relative Density. | 1.31g/cm3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| Solubility Information | H2O: 5.38 mg/mL (10.08 mM), Sonication is recommended. | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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