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Antazoline
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Catalog No. T7477Cas No. 91-75-8
Antazoline has antihistamine and anticholinergic effects.It used to treat a variety of arrhythmias.
Antazoline
Copy Product Info🥰Excellent
Catalog No. T7477Cas No. 91-75-8
Antazoline has antihistamine and anticholinergic effects.It used to treat a variety of arrhythmias.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 10 mg | $39 | In Stock | - | |
| 25 mg | $62 | In Stock | - | |
| 50 mg | $91 | In Stock | - | |
| 100 mg | $133 | In Stock | - | |
| 1 mL x 10 mM (in DMSO) | $39 | In Stock | - |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:≥95%
Appearance:Solid
Color:White
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Product Introduction
Antazoline AI Summary
Antazoline exhibits a broad range of bioactivities across multiple pathways and targets. It is notably an antagonist at the histamine H1 receptor in guinea-pig ileum with a Kd value of 72.44 nM. It also inhibits Histamine H2 receptor activity, showing relative antagonistic activity greater than 1.0. In addition, it shows bioactivity in inhibiting Ovalbumin-induced rhinitis in anesthetized rats via nasal perfusion with an IC50 value of 1260.0 nM. The compound demonstrates inhibition of acid sphingomyelinase (ASM) in human H4 cells, retaining nearly full activity at a 10 μM concentration. Furthermore, compound 258709 exhibits bioactivities against various targets, such as MLL CXXC domain-DNA interaction, Thyroid Stimulating Hormone Receptor, Anthrax Lethal Toxin internalization, and more. It shows low potency in inhibiting the BSEP transporter with an IC50 greater than 1,000,000 nM. Additionally, it has antiviral activity against SARS-CoV-2 with an IC50 value greater than 20,000.0 nM. Antazoline also displays binding affinity toward multiple receptors including HRH1, ADRA1A, HRH3, and more, and inhibits enzymes such as PDE6A, PDE4D, and PDE3A with AC50 values between 1200.0 and 6800.0 nM. The compound has a partition coefficient log P of 4.24 and a measured dissociation constant pKa of 10.1. Overall, Antazoline's diverse bioactivities make it a compound of interest for further pharmacological investigation..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Antazoline has antihistamine and anticholinergic effects.It used to treat a variety of arrhythmias. |
| Molecular Weight | 265.35 |
| Formula | C17H19N3 |
| Cas No. | 91-75-8 |
| Smiles | N(CC1=CC=CC=C1)(CC=2NCCN2)C3=CC=CC=C3 |
| Relative Density. | 1.188 g/cm3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 53 mg/mL (199.74 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (7.54 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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