VEGFR-2-IN-70 is a potent VEGFR-2 inhibitor with an IC50 of 18.04 nM. It exhibits cytotoxicity against A549 and MCF-7 cancer cells, with IC50 values of 0.43 μM and 3.8 μM, respectively. The compound induces G1 phase cell cycle arrest and apoptosis (apoptosis) in lung cancer cells. VEGFR-2-IN-70 is applicable in cancer research.

VEGFR2:18.04 nM

VEGFR-2-IN-70 (Compound 12g) inhibits the growth of A549 and MCF-7 cancer cells at concentrations ranging from 0.01 to 100 μM over 48 hours, with IC50 values of 0.43 μM and 3.86 μM, respectively. At 0.43 μM, VEGFR-2-IN-70 suppresses the migration of A549 cells within 0 to 72 hours. Additionally, a concentration of 0.43 μM over 48 hours promotes apoptosis in A549 cells, increases the expression of pro-apoptotic genes, and inhibits cell growth by inducing cell cycle arrest at the G1 phase.