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VEGFR-2-IN-70
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Catalog No. T211536
VEGFR-2-IN-70 is a potent VEGFR-2 inhibitor with an IC50 of 18.04 nM. It exhibits cytotoxicity against A549 and MCF-7 cancer cells, with IC50 values of 0.43 μM and 3.8 μM, respectively. The compound induces G1 phase cell cycle arrest and apoptosis (apoptosis) in lung cancer cells. VEGFR-2-IN-70 is applicable in cancer research.
VEGFR-2-IN-70
VEGFR-2-IN-70
Copy Product Info😃Good
Catalog No. T211536
VEGFR-2-IN-70 is a potent VEGFR-2 inhibitor with an IC50 of 18.04 nM. It exhibits cytotoxicity against A549 and MCF-7 cancer cells, with IC50 values of 0.43 μM and 3.8 μM, respectively. The compound induces G1 phase cell cycle arrest and apoptosis (apoptosis) in lung cancer cells. VEGFR-2-IN-70 is applicable in cancer research.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | Inquiry | Inquiry | |
| 50 mg | Inquiry | Inquiry | Inquiry |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | VEGFR-2-IN-70 is a potent VEGFR-2 inhibitor with an IC50 of 18.04 nM. It exhibits cytotoxicity against A549 and MCF-7 cancer cells, with IC50 values of 0.43 μM and 3.8 μM, respectively. The compound induces G1 phase cell cycle arrest and apoptosis (apoptosis) in lung cancer cells. VEGFR-2-IN-70 is applicable in cancer research. |
| Targets&IC50 | VEGFR2:18.04 nM |
| In vitro | VEGFR-2-IN-70 (Compound 12g) inhibits the growth of A549 and MCF-7 cancer cells at concentrations ranging from 0.01 to 100 μM over 48 hours, with IC50 values of 0.43 μM and 3.86 μM, respectively. At 0.43 μM, VEGFR-2-IN-70 suppresses the migration of A549 cells within 0 to 72 hours. Additionally, a concentration of 0.43 μM over 48 hours promotes apoptosis in A549 cells, increases the expression of pro-apoptotic genes, and inhibits cell growth by inducing cell cycle arrest at the G1 phase. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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