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Anti-Phospho-HIRA (Thr555) Polyclonal Antibody 2
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Catalog No. TMAB-10789
Anti-Phospho-HIRA (Thr555) Polyclonal Antibody 2 is a Rabbit antibody targeting Phospho-HIRA (Thr555). Anti-Phospho-HIRA (Thr555) Polyclonal Antibody 2 can be used in WB.
Anti-Phospho-HIRA (Thr555) Polyclonal Antibody 2
Anti-Phospho-HIRA (Thr555) Polyclonal Antibody 2
😃Good
Catalog No. TMAB-10789
Anti-Phospho-HIRA (Thr555) Polyclonal Antibody 2 is a Rabbit antibody targeting Phospho-HIRA (Thr555). Anti-Phospho-HIRA (Thr555) Polyclonal Antibody 2 can be used in WB.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $220 | 7-10 days | 7-10 days | |
| 100 μL | $374 | 7-10 days | 7-10 days | |
| 200 μL | $528 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-Phospho-HIRA (Thr555) Polyclonal Antibody 2 is a Rabbit antibody targeting Phospho-HIRA (Thr555). Anti-Phospho-HIRA (Thr555) Polyclonal Antibody 2 can be used in WB. |
| Ig Type | IgG |
| Reactivity | Human,Mouse (predicted:Rat,Dog,Pig,Cow,Horse,Rabbit,Sheep) |
| Application | |
| Recommended Dose | WB: 1:500-2000 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Nucleus. Nucleus > PML body. Primarily, though not exclusively, localized to the nucleus. Localizes to PML bodies immediately prior to onset of senescence. |
| Tissue Specificity | Expressed at high levels in kidney, pancreas and skeletal muscle and at lower levels in brain, heart, liver, lung, and placenta. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | This gene encodes a histone chaperone that preferentially places the variant histone H3.3 in nucleosomes. Orthologs of this gene in yeast, flies, and plants are necessary for the formation of transcriptionally silent heterochomatin. This gene plays an important role in the formation of the senescence-associated heterochromatin foci. These foci likely mediate the irreversible cell cycle changes that occur in senescent cells. It is considered the primary candidate gene in some haploinsufficiency syndromes such as DiGeorge syndrome, and insufficient production of the gene may disrupt normal embryonic development. [provided by RefSeq, Jul 2008] |
| Immunogen | KLH conjugated synthesised phosphopeptide: human HIRA around the phosphorylation site of Thr555 |
| Antigen Species | Human |
| Gene Name | HIRA |
| Gene ID | |
| Protein Name | Protein HIRA |
| Uniprot ID | |
| Function | Cooperates with ASF1A to promote replication-independent chromatin assembly. Required for the periodic repression of histone gene transcription during the cell cycle. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit. |
| Molecular Weight | Theoretical: 112 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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