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Diphenyl disulfide

Name: Diphenyl disulfide
Brand: TargetMol
SKU: T37518
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T37518Cas No. 882-33-7

Alias Phenyl disulfide

Diphenyl disulfide (Phenyl disulfide) shows anticancer activity in breast cancer cell lines.Diphenyl disulfide induces and enhances apoptosis in breast cancer cells through Bax protein hydrolysis activation and concomitant autophagy.Diphenyl disulfide inhibits cell proliferation and viability and reduces colony formation in a dose-dependent manner. Diphenyl disulfide can be used to treat breast cancer.

Diphenyl disulfide

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Purity: 99.95%

Catalog No. T37518Alias Phenyl disulfideCas No. 882-33-7

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 g	$29	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.95%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Diphenyl disulfide AI Summary

Diphenyl disulfide demonstrates multiple bioactivities including inhibition of the Plasmodium falciparum KAS3 enzyme with an IC50 of 650.0 nM, antimalarial activity against chloroquine-sensitive Plasmodium falciparum W2 with an IC50 of 6700.0 nM, and chloroquine-resistant Plasmodium falciparum D6 with an IC50 of 5000.0 nM. It also exhibits cytotoxicity towards mouse J774.G8 cells with an IC50 of 123800.0 nM, resulting in a therapeutic index of 12.4 when considering its effect on chloroquine-sensitive Plasmodium falciparum W2. The compound interacts with a variety of cellular processes, such as enhancing SMN2 splice variant expression, inhibiting tau fibril formation, modulating lipid storage, and inhibiting enzymes like PPTase and aldolase. Furthermore, Diphenyl disulfide inhibits recombinant human N-terminal His6-tagged and C-terminal Strep-tagged MAGL in Escherichia coli Rosetta with an IC50 of 1600.0 nM, and inhibits wild-type full-length human liver FBPase expressed in Escherichia coli BL21 (DE3) with an IC50 value greater than 10,000.0 nM, showing a 10.37% inhibition at a concentration of 10 µM in a malachite green dye-based assay. These activities suggest significant effects on enzyme functioning and protein interactions..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

Synonyms

Phenyl disulfide

Chemical Properties

Molecular Weight	218.34
Formula	C₁₂H₁₀S₂
Cas No.	882-33-7
Smiles	S(SC1=CC=CC=C1)C1=CC=CC=C1
Relative Density.	1.353 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (229 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (9.16 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.5800 mL	22.9001 mL	45.8001 mL	229.0006 mL
5 mM	0.9160 mL	4.5800 mL	9.1600 mL	45.8001 mL
10 mM	0.4580 mL	2.2900 mL	4.5800 mL	22.9001 mL
20 mM	0.2290 mL	1.1450 mL	2.2900 mL	11.4500 mL
50 mM	0.0916 mL	0.4580 mL	0.9160 mL	4.5800 mL
100 mM	0.0458 mL	0.2290 mL	0.4580 mL	2.2900 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc