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Compstatin

Name: Compstatin
Brand: TargetMol
SKU: TP1304
Price: 73 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TP1304Cas No. 206645-99-0

Compstatin is a cyclic peptide consisting of 13 amino acid residues and is a potent inhibitor of complement system C3. Compstatin is species-specific and has inhibitory effects only on the complement system of primates. Studies have shown that it can bind to baboon C3 and is resistant to proteolytic cleavage in baboon blood. Its IC50 values for the classical pathway and alternative pathway are 63 μM and 12 μM, respectively.

Compstatin

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Catalog No. TP1304Cas No. 206645-99-0

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$73	In Stock	In Stock
5 mg	$179	In Stock	In Stock
10 mg	$272	In Stock	In Stock
25 mg	$458	In Stock	In Stock
50 mg	$663	In Stock	In Stock
100 mg	$927	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:>99.99%

Appearance:Solid

Color:White

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COA

Product Introduction

Compstatin AI Summary

Compstatin demonstrates inhibitory effects on various components of the complement system. It inhibits C3 convertase with an IC50 value of 3400.0 nM and shows inhibition of C3 cleavage, which affects the activity of C3/C5 convertase, with an IC50 value of 12000.0 nM. Additionally, Compstatin inhibits the activation of C3b, as indicated by a logIC50 value of 0.0 compared to compstatin. The compound also inhibits the binding of C3 to the convertase in the alternative pathway (IC50 = 12000.0 nM) and the classical pathway (IC50 = 63000.0 nM), with greater efficacy in the alternative pathway. Furthermore, it has a binding affinity to complement component C3 in human plasma with a Kd of 1300.0 nM, and to complement component C3c with a Kd of 390.0 nM. Compstatin shows high solubility in PBS at pH 7.4, with a solubility of 4500.0 ug/mL determined over a period of 24 to 48 hours. These properties highlight its potential as a modulator of the complement system response..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

Chemical Properties

Molecular Weight	1550.77
Formula	C₆₆H₉₉N₂₃O₁₇S₂
Cas No.	206645-99-0
Smiles	CC[C@H](C)[C@H](N)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)CNC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)C(C)C)C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(N)=O
Relative Density.	1.56 g/cm3 (Predicted)
Sequence	Ile-Cys-Val-Val-Gln-Asp-Trp-Gly-His-His-Arg-Cys-Thr-NH2 (Disulfide bridge: Cys2-Cys12)
Sequence Short	ICVVQDWGHHRCT (Disulfide bridge: Cys2-Cys12)

Storage & Solubility Information

Storage

keep away from moisture | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 115 mg/mL (74.16 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	0.6448 mL	3.2242 mL	6.4484 mL	32.2420 mL
5 mM	0.1290 mL	0.6448 mL	1.2897 mL	6.4484 mL
10 mM	0.0645 mL	0.3224 mL	0.6448 mL	3.2242 mL
20 mM	0.0322 mL	0.1612 mL	0.3224 mL	1.6121 mL
50 mM	0.0129 mL	0.0645 mL	0.1290 mL	0.6448 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc