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2-Deoxy-2-fluoro-L-fucose

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Catalog No. T41359Cas No. 70763-62-1

2-Deoxy-2-fluoro-L-fucose is a fucosylation inhibitor that inhibits the de novo synthesis of GDP-fucose in mammalian cells, effectively inhibits the proliferation of human cancer and primary endothelial cells, and has potential as an angiogenic therapeutic agent. It also inhibits fucosylation of plant cell wall polysaccharides, particularly affecting the dimerization of the pectin-like polysaccharide RG-II, thereby inhibiting root growth and cell elongation.2-Deoxy-2-fluoro-L-fucose also reduces the phosphorylation of Smad 1/5 and Smad 2 in 4T1 cells.

2-Deoxy-2-fluoro-L-fucose

2-Deoxy-2-fluoro-L-fucose

🥰Excellent
Purity: 99.87%
Catalog No. T41359Cas No. 70763-62-1
2-Deoxy-2-fluoro-L-fucose is a fucosylation inhibitor that inhibits the de novo synthesis of GDP-fucose in mammalian cells, effectively inhibits the proliferation of human cancer and primary endothelial cells, and has potential as an angiogenic therapeutic agent. It also inhibits fucosylation of plant cell wall polysaccharides, particularly affecting the dimerization of the pectin-like polysaccharide RG-II, thereby inhibiting root growth and cell elongation.2-Deoxy-2-fluoro-L-fucose also reduces the phosphorylation of Smad 1/5 and Smad 2 in 4T1 cells.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$78-In Stock
5 mg$188-In Stock
10 mg$312-In Stock
25 mg$625-In Stock
50 mg$980-In Stock
100 mg$1,590-In Stock
200 mg$2,170-In Stock
1 mL x 10 mM (in DMSO)$198-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.87%
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Product Introduction

Bioactivity
Description
2-Deoxy-2-fluoro-L-fucose is a fucosylation inhibitor that inhibits the de novo synthesis of GDP-fucose in mammalian cells, effectively inhibits the proliferation of human cancer and primary endothelial cells, and has potential as an angiogenic therapeutic agent. It also inhibits fucosylation of plant cell wall polysaccharides, particularly affecting the dimerization of the pectin-like polysaccharide RG-II, thereby inhibiting root growth and cell elongation.2-Deoxy-2-fluoro-L-fucose also reduces the phosphorylation of Smad 1/5 and Smad 2 in 4T1 cells.
In vitro
Methods: 4T1 cells were treated with 2-Deoxy-2-fluoro-L-fucose (100, 250, 500 μM) and the Aleuria aurantia lectin (AAL) in the lysates was detected by Western Blot.
Results: 2-Deoxy-2-fluoro-L-fucose reduced the AAL signal at all concentrations and inhibited fucosylation.
Methods: 4T1 cells were treated with 2-Deoxy-2-fluoro-L-fucose (100 μM, 48 hours) and then plated for live cell migration analysis; Smad protein expression was assessed, and changes in signaling molecules that regulate migration were evaluated.
Results: Cells treated with 2-Deoxy-2-fluoro-L-fucose had impaired migration and decreased phosphorylation of Smad 1/5 and Smad 2. [1]
Chemical Properties
Molecular Weight166.15
FormulaC6H11FO4
Cas No.70763-62-1
SmilesC[C@H](O)[C@@H](O)[C@@H](O)[C@H](F)C=O
Relative Density.1.335 g/cm3 (Predicted)
Storage & Solubility Information
Storagekeep away from direct sunlight,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 80 mg/mL (481.49 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (19.86 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM6.0187 mL30.0933 mL60.1866 mL300.9329 mL
5 mM1.2037 mL6.0187 mL12.0373 mL60.1866 mL
10 mM0.6019 mL3.0093 mL6.0187 mL30.0933 mL
20 mM0.3009 mL1.5047 mL3.0093 mL15.0466 mL
50 mM0.1204 mL0.6019 mL1.2037 mL6.0187 mL
100 mM0.0602 mL0.3009 mL0.6019 mL3.0093 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
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Keywords

2-Deoxy-2-fluoro-L-fucose2Deoxy2fluoroLfucose2 Deoxy 2 fluoro L fucose
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