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2-Deoxy-2-fluoro-L-fucose

Name: 2-Deoxy-2-fluoro-L-fucose
Brand: TargetMol
SKU: T41359
Price: 71 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T41359Cas No. 70763-62-1

2-Deoxy-2-fluoro-L-fucose is a fucosylation inhibitor that inhibits the de novo synthesis of GDP-fucose in mammalian cells, effectively inhibits the proliferation of human cancer and primary endothelial cells, and has potential as an angiogenic therapeutic agent. It also inhibits fucosylation of plant cell wall polysaccharides, particularly affecting the dimerization of the pectin-like polysaccharide RG-II, thereby inhibiting root growth and cell elongation.2-Deoxy-2-fluoro-L-fucose also reduces the phosphorylation of Smad 1/5 and Smad 2 in 4T1 cells.

2-Deoxy-2-fluoro-L-fucose

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Purity: 99.87%

Catalog No. T41359Cas No. 70763-62-1

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$71	-	In Stock
5 mg	$179	-	In Stock
10 mg	$278	-	In Stock
25 mg	$596	-	In Stock
50 mg	$893	-	In Stock
100 mg	$1,320	-	In Stock
1 mL x 10 mM (in DMSO)	$142	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.87%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description

In vitro

Methods: 4T1 cells were treated with 2-Deoxy-2-fluoro-L-fucose (100, 250, 500 μM) and the Aleuria aurantia lectin (AAL) in the lysates was detected by Western Blot.
Results: 2-Deoxy-2-fluoro-L-fucose reduced the AAL signal at all concentrations and inhibited fucosylation.
Methods: 4T1 cells were treated with 2-Deoxy-2-fluoro-L-fucose (100 μM, 48 hours) and then plated for live cell migration analysis; Smad protein expression was assessed, and changes in signaling molecules that regulate migration were evaluated.
Results: Cells treated with 2-Deoxy-2-fluoro-L-fucose had impaired migration and decreased phosphorylation of Smad 1/5 and Smad 2. [1]

Chemical Properties

Molecular Weight	166.15
Formula	C₆H₁₁FO₄
Cas No.	70763-62-1
Smiles	C[C@H](O)[C@@H](O)[C@@H](O)[C@H](F)C=O
Relative Density.	1.335 g/cm3 (Predicted)

Storage & Solubility Information

Storage

keep away from direct sunlight,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (481.49 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (19.86 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	6.0187 mL	30.0933 mL	60.1866 mL	300.9329 mL
5 mM	1.2037 mL	6.0187 mL	12.0373 mL	60.1866 mL
10 mM	0.6019 mL	3.0093 mL	6.0187 mL	30.0933 mL
20 mM	0.3009 mL	1.5047 mL	3.0093 mL	15.0466 mL
50 mM	0.1204 mL	0.6019 mL	1.2037 mL	6.0187 mL
100 mM	0.0602 mL	0.3009 mL	0.6019 mL	3.0093 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc