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LEP(116-130)(mouse)
🥰Excellent
Catalog No. TP1305Cas No. 258276-95-8
Leptin (116-130),mouse(C64H109N19O24S),a peptide with the sequence Ser-Cys-Ser-Leu-Pro-Gln-Thr-Ser-Gly-Leu-Gln-Lys-Pro-Glu-Ser-NH2. Leptin is an adipocyte-derived hormone that acts as a major regulator for food intake and energy homeostasis.
LEP(116-130)(mouse)
🥰Excellent
Catalog No. TP1305Cas No. 258276-95-8
Leptin (116-130),mouse(C64H109N19O24S),a peptide with the sequence Ser-Cys-Ser-Leu-Pro-Gln-Thr-Ser-Gly-Leu-Gln-Lys-Pro-Glu-Ser-NH2. Leptin is an adipocyte-derived hormone that acts as a major regulator for food intake and energy homeostasis.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $85 | In Stock | |
| 2 mg | $133 | In Stock | |
| 5 mg | $259 | In Stock | |
| 10 mg | $426 | In Stock | |
| 25 mg | $691 | In Stock | |
| 50 mg | $963 | In Stock | |
| 100 mg | $1,280 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Leptin (116-130),mouse(C64H109N19O24S),a peptide with the sequence Ser-Cys-Ser-Leu-Pro-Gln-Thr-Ser-Gly-Leu-Gln-Lys-Pro-Glu-Ser-NH2. Leptin is an adipocyte-derived hormone that acts as a major regulator for food intake and energy homeostasis. |
| In vitro | LEP-(116-130) (300 µM) fails to inhibit AP-OB binding and does not activate OB-Rb signal transduction in vitro[1]. |
| In vivo | Administration of LEP-(116-130) (1 mg, i.p.) results in decreased body weight gain, even with increased food consumption relative to vehicle-injected control mice. It significantly reduces blood glucose levels by approximately 100 mg/dL. However, in wild-type (+/+) C57BLKS/J-m mice, LEP-(116-130) does not affect thermoregulation over 4 or 7 days[1]. |
| Molecular Weight | 1560.73 |
| Formula | C64H109N19O24S |
| Cas No. | 258276-95-8 |
| Smiles | CC(C)C[C@H](NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CS)NC(=O)[C@@H](N)CO)[C@@H](C)O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(N)=O |
| Relative Density. | 1.372 g/cm3 (Predicted) |
| Sequence | Ser-Cys-Ser-Leu-Pro-Gln-Thr-Ser-Gly-Leu-Gln-Lys-Pro-Glu-Ser-NH2 |
| Sequence Short | SCSLPQTSGLQKPES-NH2 |
Storage & Solubility Information
| Storage | keep away from moisture | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| Solubility Information | DMSO: 10 mM, Sonication is recommended. | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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