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LEP(116-130)(mouse)

Name: LEP(116-130)(mouse)
Brand: TargetMol
SKU: TP1305
Price: 85 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TP1305Cas No. 258276-95-8

Leptin (116-130),mouse(C64H109N19O24S),a peptide with the sequence Ser-Cys-Ser-Leu-Pro-Gln-Thr-Ser-Gly-Leu-Gln-Lys-Pro-Glu-Ser-NH2. Leptin is an adipocyte-derived hormone that acts as a major regulator for food intake and energy homeostasis.

LEP(116-130)(mouse)

🥰Excellent

Catalog No. TP1305Cas No. 258276-95-8

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$85	In Stock	In Stock
2 mg	$133	In Stock	In Stock
5 mg	$259	In Stock	In Stock
10 mg	$426	In Stock	In Stock
25 mg	$691	In Stock	In Stock
50 mg	$963	In Stock	In Stock
100 mg	$1,280	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:>99.99%

Appearance:Solid

Color:White

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COA

Product Introduction

Bioactivity

Description	Leptin (116-130),mouse(C64H109N19O24S),a peptide with the sequence Ser-Cys-Ser-Leu-Pro-Gln-Thr-Ser-Gly-Leu-Gln-Lys-Pro-Glu-Ser-NH2. Leptin is an adipocyte-derived hormone that acts as a major regulator for food intake and energy homeostasis.
In vitro	LEP-(116-130) (300 µM) fails to inhibit AP-OB binding and does not activate OB-Rb signal transduction in vitro[1].
In vivo	Administration of LEP-(116-130) (1 mg, i.p.) results in decreased body weight gain, even with increased food consumption relative to vehicle-injected control mice. It significantly reduces blood glucose levels by approximately 100 mg/dL. However, in wild-type (+/+) C57BLKS/J-m mice, LEP-(116-130) does not affect thermoregulation over 4 or 7 days[1].

Chemical Properties

Molecular Weight	1560.73
Formula	C₆₄H₁₀₉N₁₉O₂₄S
Cas No.	258276-95-8
Smiles	CC(C)C[C@H](NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CS)NC(=O)[C@@H](N)CO)[C@@H](C)O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(N)=O
Relative Density.	1.372 g/cm3 (Predicted)
Sequence	Ser-Cys-Ser-Leu-Pro-Gln-Thr-Ser-Gly-Leu-Gln-Lys-Pro-Glu-Ser-NH2
Sequence Short	SCSLPQTSGLQKPES

Storage & Solubility Information

Storage

keep away from moisture | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 10 mM, Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	0.6407 mL	3.2036 mL	6.4073 mL	32.0363 mL
5 mM	0.1281 mL	0.6407 mL	1.2815 mL	6.4073 mL
10 mM	0.0641 mL	0.3204 mL	0.6407 mL	3.2036 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc