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DHMEQ racemate

Name: DHMEQ racemate
Brand: TargetMol
SKU: T11018
Rating: 4.5 (1 reviews)

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Catalog No. T11018Cas No. 287194-38-1

Alias rel-DHMEQ

DHMEQ racemate is an NF-κB inhibitor. The activity of DHMEQ racemate is lower than (-)-DHMEQ.

DHMEQ racemate

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Catalog No. T11018Alias rel-DHMEQCas No. 287194-38-1

DHMEQ racemate is an NF-κB inhibitor. The activity of DHMEQ racemate is lower than (-)-DHMEQ.

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$1,670	6-8 weeks	6-8 weeks
50 mg	$2,180	6-8 weeks	6-8 weeks
100 mg	$2,800	6-8 weeks	6-8 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	DHMEQ racemate is an NF-κB inhibitor. The activity of DHMEQ racemate is lower than (-)-DHMEQ.
In vitro	DHMEQ racemate (DHM3EQ) and (-)-DHMEQ (DHM2EQ) inhibit TNF-a-induced NF-kB activation, with (-)-DHMEQ being more effective and less toxic.
In vivo	The anti-arthritis effect of (-)-DHMEQ (DHM2EQ) and DHMEQ racemate (DHM3EQ) on type II collagen-induced arthritis in DBA1/J mice was studied. Because of its pathological similarity to human rheumatoid arthritis, this animal model is widely used to evaluate anti-rheumatic drugs. Cause arthritis and score it. (-)-DHMEQ significantly inhibited type II collagen-induced arthritis in mice, while DHMEQ racemates tended to only slightly inhibit it.
Synonyms	rel-DHMEQ

Chemical Properties

Molecular Weight	261.23
Formula	C₁₃H₁₁NO₅
Cas No.	287194-38-1
Smiles	O[C@@H]1[C@]2([C@](O2)(C(=O)C=C1NC(=O)C3=C(O)C=CC=C3)[H])[H]
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 32 mg/mL (122.5 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.8280 mL	19.1402 mL	38.2804 mL	191.4022 mL
5 mM	0.7656 mL	3.8280 mL	7.6561 mL	38.2804 mL
10 mM	0.3828 mL	1.9140 mL	3.8280 mL	19.1402 mL
20 mM	0.1914 mL	0.9570 mL	1.9140 mL	9.5701 mL
50 mM	0.0766 mL	0.3828 mL	0.7656 mL	3.8280 mL
100 mM	0.0383 mL	0.1914 mL	0.3828 mL	1.9140 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc