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RH-5849

Name: RH-5849
Brand: TargetMol
SKU: T19822
Price: 36 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T19822Cas No. 112225-87-3

Alias RH5849, RH 5849, 1,2-Dibenzoyl-1-Tert-Butylhydrazine, 1,2-Dibenzoyl-1-(T-Butyl)Hydrazine

RH-5849 (1,2-Dibenzoyl-1-Tert-Butylhydrazine) is a novel Insect growth regulator that can be used as a potential insecticide to control olive fruit fly.

RH-5849

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Purity: 99.82%

Catalog No. T19822Alias RH5849, RH 5849, 1,2-Dibenzoyl-1-Tert-Butylhydrazine, 1,2-Dibenzoyl-1-(T-Butyl)HydrazineCas No. 112225-87-3

RH-5849 (1,2-Dibenzoyl-1-Tert-Butylhydrazine) is a novel Insect growth regulator that can be used as a potential insecticide to control olive fruit fly.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
100 mg	$36	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$39	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.82%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

RH-5849 AI Summary

RH-5849 exhibits various bioactivities and physicochemical properties conducive for insecticidal applications. It shows good membrane permeability through artificial membranes with a Papp value of 16.52 x 10^-6 cm/s and a moderate hydrophobicity, indicated by a LogP value of 2.45. However, it demonstrates low permeability across Caco-2 cell membranes with LogPapp values of -4.34 and -4.42. The compound has a partition coefficient (LogD) of 2.45 in octanol-buffer and octanol-water and a low dissociation constant (pKa) of 0.0 at pH 7.3. In terms of bioactivity, RH-5849 is a potent inhibitor of DNA Polymerase Beta (IC50 = 89125.1 nM) and GCN5L2 (IC50 = 7079.5 nM). It also exhibits significant ecdysone receptor agonist activity in insect cells, with EC50 values of 1819.7 nM in Drosophila melanogaster B2 cells and 426.58 nM in Bombyx mori Bm5 cells. The compound shows pronounced insecticidal activity against various pests. It is particularly effective against the Oriental armyworm (Mythimna separata), causing 70% mortality at 25 mg/kg and 100% mortality at 50 mg/kg on pretreated corn leaves. Similarly, it shows a high mortality rate in Anastrepha suspensa and Bactrocera oleae, with over 75% mortality and complete mortality at specified concentrations, respectively. Additionally, it exhibits lower efficacy in fufenozide-resistant Plutella xylostella, with an LC50 of 114.2 ug/mL compared to 10.6 ug/mL in susceptible larvae. These findings underscore RH-5849's potential as a selective and effective insecticide, particularly against specific pest species, while also offering utility as a biochemical tool in research concerning ecdysone signaling pathways..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	RH-5849 (1,2-Dibenzoyl-1-Tert-Butylhydrazine) is a novel Insect growth regulator that can be used as a potential insecticide to control olive fruit fly.
Synonyms	RH5849, RH 5849, 1,2-Dibenzoyl-1-Tert-Butylhydrazine, 1,2-Dibenzoyl-1-(T-Butyl)Hydrazine

Chemical Properties

Molecular Weight	296.36
Formula	C₁₈H₂₀N₂O₂
Cas No.	112225-87-3
Smiles	CC(C)(C)N(NC(=O)C1=CC=CC=C1)C(=O)C1=CC=CC=C1
Relative Density.	1.128g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (185.59 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 5 mg/mL (16.87 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3743 mL	16.8714 mL	33.7427 mL	168.7137 mL
5 mM	0.6749 mL	3.3743 mL	6.7485 mL	33.7427 mL
10 mM	0.3374 mL	1.6871 mL	3.3743 mL	16.8714 mL
20 mM	0.1687 mL	0.8436 mL	1.6871 mL	8.4357 mL
50 mM	0.0675 mL	0.3374 mL	0.6749 mL	3.3743 mL
100 mM	0.0337 mL	0.1687 mL	0.3374 mL	1.6871 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc